Lack of integrative control of heat production and heat loss after capsaicin administration
Lack of integrative control of heat production and heat loss after capsaicin administration
复制标题
施用辣椒素后缺乏对热量产生和热量损失的综合控制
DOI：
--
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
S. Kimura
中科院分区：
文献类型：
--
作者：
T. Osaka;A. Kobayashi;Tai;Y. Namba;S. Inoue;S. Kimura
抽象的。体温通常是通过对产热和散热的相反控制来调节的。然而，辣椒素的全身给药同时激活热损失和热产生。由于辣椒素受体主要位于初级感觉神经元上，并且体温由中枢神经系统调节，因此我们研究了这些辣椒素诱导的热反应所涉及的脑机制。为此，我们研究了脊髓化和去大脑对这些反应的影响，在人工通气，麻醉大鼠。颈椎横断在很大程度上减弱了这两种反应，表明大脑的重要参与。结肠温度（Tc）没有改变后，辣椒素管理脊髓大鼠。下丘脑和中脑之间的去大脑阻止辣椒素诱导的热损失，并增强辣椒素诱导的产热。因此，Tc增加而无低体温期。结果表明，辣椒素分别激活脑干控制的产热和前脑控制的散热。
Abstract. Body temperature is usually regulated by opposing controls of heat production and heat loss. However, systemic administration of capsaicin activates heat loss and heat production simultaneously. Because capsaicin receptors are located mainly on primary sensory neurons and body temperature is regulated by the central nervous system, we investigated the brain mechanisms involved in these capsaicin-induced thermal responses. For this purpose, we examined the effects of spinalization and decerebration on these responses in artificially ventilated, urethane-anesthetized rats. Cervical spinal transection largely attenuated both responses, showing the critical involvement of the brain. Colonic temperature (Tc) did not change after the capsaicin administration to the spinalized rats. Decerebration between the hypothalamus and midbrain prevented the capsaicin-induced heat loss and enhanced the capsaicin-induced heat production. Consequently, Tc increased without a hypothermic period. The results show that capsaicin activates brainstem-controlled heat production and forebrain-controlled heat loss separately.
大鼠慢性颈脊髓损伤和自主神经反射亢进。
DOI：
10.1152/ajpregu.1990.258.1.r169
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Osborn,JW;Taylor,RF;Schramm,LP
通讯作者：
Schramm,LP