Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells.
Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells.
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DOI：
10.1038/s41598-017-06879-5
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发表时间：
2017-07-27
影响因子：
4.6
通讯作者：
Tachibana H
中科院分区：
文献类型：
--
作者：
Bae J;Kumazoe M;Yamashita S;Tachibana H
硫化氢(H_2S)是一种带有臭鸡蛋味的无色气体，最近被认为是与体内平衡、血管系统和炎症系统调节有关的生理活动的信号媒介。在这里，我们显示了硫化氢供体，包括硫化氢钠(NaHS)，GYY-4137和二烯丙基三硫化物(DATS)，协同增强了绿茶多酚(−)-表没食子儿茶素没食子酸酯(EGCG)对多发性骨髓瘤细胞的抗癌作用，而不影响正常细胞。NaHS显著增强了EGCG的抗癌作用，并延长了小鼠异种移植模型的存活时间。在这一机制中，H_2S通过环鸟苷一磷酸(CGMP)/酸性鞘磷脂酶途径促进EGCG诱导的细胞死亡。此外，NaHS还降低了环核苷酸磷酸二酯酶的活性，该酶被称为cGMP负性调节因子。总而言之，我们确认硫化氢是一种气体递质，可以增强EGCG诱导的癌细胞死亡。
Hydrogen sulphide (H2S) is a colourless gas with the odour of rotten eggs and has recently been recognized as a signal mediator in physiological activities related with the regulation of homeostasis, the vascular system and the inflammatory system. Here we show that H2S donors, including sodium hydrogen sulphide (NaHS), GYY 4137 and diallyltrisulfide (DATS), synergistically enhanced the anti-cancer effect of a green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) against multiple myeloma cells without affecting normal cells. NaHS significantly potentiated the anti-cancer effect of EGCG and prolonged survival in a mouse xenograft model. In this mechanism, H2S enhanced apoptotic cell death through cyclic guanosine monophosphate (cGMP)/acid sphingomyelinase pathway induced by EGCG. Moreover, NaHS reduced the enzyme activity of cyclic nucleotide phosphodiesterase that is known as cGMP negative regulator. In conclusion, we identified H2S as a gasotransmitter that potentiates EGCG-induced cancer cell death.
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影响因子：
7.3
作者：
Mustafa AK;Gadalla MM;Snyder SH
通讯作者：
Snyder SH
DOI：
10.1124/jpet.105.083634
发表时间：
2005-07-01
影响因子：
3.5
作者：
Linder, AE;McCluskey, LP;Webb, RC
通讯作者：
Webb, RC
影响因子：
6.6
作者：
Kabil, Omer;Vitvitsky, Victor;Banerjee, Ruma
通讯作者：
Banerjee, Ruma
影响因子：
3.5
作者：
Loughney, K;Hill, TR;Ferguson, K
通讯作者：
Ferguson, K
DOI：
10.1161/atvbaha.110.209783
发表时间：
2010-10-01
影响因子：
8.7
作者：
Bucci, Mariarosaria;Papapetropoulos, Andreas;Cirino, Giuseppe
通讯作者：
Cirino, Giuseppe