Understanding associative false memories in aging using multivariate analyses.
Understanding associative false memories in aging using multivariate analyses.
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DOI：
10.1080/13825585.2022.2037500
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发表时间：
2022-05
影响因子：
1.9
通讯作者：
Gerver, Courtney R.
中科院分区：
文献类型：
--
作者：
Dennis, Nancy A.;Overman, Amy A.;Carpenter, Catherine M.;Gerver, Courtney R.
与记忆相关的联想记忆下降是普遍存在的，已经在广泛的刺激和实验范式中观察到。研究进一步表明，这种行为辨别力的下降是由于对重组诱饵的错误记忆增加所致。目前的研究探讨了相关的错误记忆的神经基础，通过使用表征相似性分析，以检查在检索过程中的编码表示的重新激活的年龄差异和神经重叠的神经模式的相似性的基础目标和相关的诱惑在检索过程中。在行为上，我们观察到与年龄相关的d '减少，这表明是由老年人中错误警报的增加所驱动的。虽然我们没有发现年龄差异的神经活动模式之间的关系的基础击中跨记忆阶段（ERS测量），神经模式的相似性的基础目标和诱惑受年龄的影响。具体来说，虽然年轻人和老年人表现出整体较高的模式相似性之间的命中和CR相比，命中和FA（如RSA测量），这种差异减少了老年人枕叶皮质。此外，更大的命中FA表征相似性与枕叶，额叶和顶叶皮质的关联FA增加。结果表明，虽然目标的神经表征可能不会因年龄而异，但目标和诱饵的神经表征之间更大的模式相似性可能反映了记忆中编码的信息的独特性降低，因此新旧项目更难以区分，导致更多的误报。
Age-related declines in associative memory are ubiquitous, having been observed across a wide array of stimuli and experimental paradigms. Research further shows that such decreases in behavioral discriminability arise from increases in false memories for recombined lures. The current study examined the underlying neural basis of associative false memories by using representational similarity analyses to examine both age differences in the reactivation of encoded representations during retrieval and the neural overlap in the similarity of neural patterns underlying targets and related lures during retrieval. Behaviorally, we observed an age-related reduction in d’, which was shown to be driven by increased false alarms in the older adults. While we found no age difference in the relationship between patterns of neural activity underlying hits across memory phases (as measured by ERS), the similarity of neural patterns underlying targets and lures was affected by age. Specifically, while younger and older adults exhibited overall higher pattern similarity between hits and CRs compared to hits and FAs (as measured by RSA), this difference was reduced in older adults within occipital cortices. Additionally, greater Hit-FA representational similarity correlated with increases in associative FAs across occipital, frontal, and parietal cortices. Results suggest that while neural representations underlying targets may not differ across age, greater pattern similarity between the neural representation of targets and lures may reflect reduced distinctiveness of the information encoded in memory, such that old and new items are more difficult to discriminate, leading to more false alarms.
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影响因子：
2.6
作者：
Earles JL;Kersten AW;Vernon LL;Starkings R
通讯作者：
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影响因子：
3.7
作者：
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影响因子：
2.9
作者：
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DOI：
10.1073/pnas.1610686113
发表时间：
2016-09-06
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
2.4
作者：
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通讯作者：
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