Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.
Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.
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DOI：
10.1016/j.jaci.2012.04.014
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发表时间：
2012-08
影响因子：
14.2
通讯作者：
Haselkorn, Tmirah
中科院分区：
文献类型：
--
作者：
Chipps, Bradley E.;Zeiger, Robert S.;Borish, Larry;Wenzel, Sally E.;Yegin, Ashley;Hayden, Mary Lou;Miller, Dave P.;Bleecker, Eugene R.;Simons, F. Estelle R.;Szefler, Stanley J.;Weiss, Scott T.;Haselkorn, Tmirah
关键词：
严重或难以治疗的哮喘患者是一个研究不足的人群，但却占了相当大的哮喘发病率、死亡率和成本。哮喘的流行病学和自然病史：结果和治疗方案(Tenor)研究是一项为期3年的大型多中心观察队列研究，涉及4756名患有严重或难以治疗的哮喘的患者(n=3489名18岁的成人≥，497名13-17岁的青少年，以及n=770名6-12岁的儿童)。Tenor的主要目标是描述这一队列中疾病的自然病史。每半年和每年评估一次的数据包括人口统计学、病史、合并症、哮喘控制、与哮喘相关的医疗保健使用、药物使用、肺功能、IgE水平、自我报告的哮喘诱因以及与哮喘相关的生活质量。我们强调了来自超过25个同行评审的男高音出版物的关键发现和临床意义。无论年龄大小，尽管接受了多种长期控制性药物治疗，患有严重或难以治疗哮喘的患者仍表现出较高的卫生保健使用率和较大的哮喘负担。近期加重病史是未来哮喘加重的最强预测因素。未控制的哮喘，如2007年国家心肺和血液研究所指南的损害领域所定义的，是非常普遍的，并预测未来哮喘的恶化；这一评估可用于识别高危患者。免疫球蛋白E和过敏原致敏作用在大多数重症或难治性哮喘患者中起作用。
Patients with severe or difficult-to-treat asthma are an understudied population but account for considerable asthma morbidity, mortality, and costs. The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study was a large, 3-year, multicenter, observational cohort study of 4756 patients (n = 3489 adults ≥18 years of age, n = 497 adolescents 13-17 years of age, and n = 770 children 6-12 years of age) with severe or difficult-to-treat asthma. TENOR's primary objective was to characterize the natural history of disease in this cohort. Data assessed semiannually and annually included demographics, medical history, comorbidities, asthma control, asthma-related health care use, medication use, lung function, IgE levels, self-reported asthma triggers, and asthma-related quality of life. We highlight the key findings and clinical implications from more than 25 peer-reviewed TENOR publications. Regardless of age, patients with severe or difficult-to-treat asthma demonstrated high rates of health care use and substantial asthma burden despite receiving multiple long-term controller medications. Recent exacerbation history was the strongest predictor of future asthma exacerbations. Uncontrolled asthma, as defined by the 2007 National Heart, Lung, and Blood Institute guidelines’ impairment domain, was highly prevalent and predictive of future asthma exacerbations; this assessment can be used to identify high-risk patients. IgE and allergen sensitization played a role in the majority of severe or difficult-to-treat asthmatic patients.
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影响因子：
4.3
作者：
Haselkorn, Tmirah;Fish, James E.;Weiss, Scott T.
通讯作者：
Weiss, Scott T.
影响因子：
14.2
作者：
Arbes, Samuel J., Jr.;Gergen, Peter J.;Zeldin, Darryl C.
通讯作者：
Zeldin, Darryl C.
哮喘流行病学和自然病史中 IgE 介导的过敏性哮喘的性别差异： 结果和治疗方案（TENOR）研究
影响因子：
1.9
作者：
Lee, JH;Haselkorn, T;Wenzel, SE
通讯作者：
Wenzel, SE
影响因子：
1.9
作者：
Haselkorn, Tmirah;Borish, Larry;Wong, Dennis A.
通讯作者：
Wong, Dennis A.
影响因子：
8.9
作者：
Chen, Hubert;Johnson, Charles A.;Israel, Elliot
通讯作者：
Israel, Elliot