Macrophage-targeted nanomedicine for the diagnosis and management of atherosclerosis.
Macrophage-targeted nanomedicine for the diagnosis and management of atherosclerosis.
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用于诊断和治疗动脉粥样硬化的巨噬细胞靶向纳米药物
DOI：
10.3389/fphar.2022.1000316
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
动脉粥样硬化是心血管疾病的主要原因，如心肌梗死和中风，这是全世界死亡人数最多的疾病。巨噬细胞是动脉粥样硬化进展的主要贡献者，因此巨噬细胞相关的病理过程被认为是动脉粥样硬化诊断和治疗的一个极其重要的靶点。然而，现有的临床策略在动脉粥样硬化的早期发现和管理方面仍存在许多瓶颈和挑战。纳米医学利用各种纳米粒子/纳米载体用于医疗目的，可以有效地装载治疗剂，显著提高其稳定性，并准确地将其递送到动脉粥样硬化斑块。本文综述了巨噬细胞靶向纳米药物在动脉粥样硬化诊断和治疗中的最新进展，并对其潜在的应用前景和临床益处进行了讨论。
Atherosclerosis is the primary cause of cardiovascular diseases, such as myocardial infarction and stroke, which account for the highest death toll worldwide. Macrophage is the major contributor to atherosclerosis progression, and therefore, macrophage-associated pathological process is considered an extremely important target for the diagnosis and treatment of atherosclerosis. However, the existing clinical strategies still have many bottlenecks and challenges in atherosclerosis’s early detection and management. Nanomedicine, using various nanoparticles/nanocarriers for medical purposes, can effectively load therapeutic agents, significantly improve their stability and accurately deliver them to the atherosclerotic plaques. In this review, we summarized the latest progress of the macrophage-targeted nanomedicine in the diagnosis and treatment of atherosclerosis, and their potential applications and clinical benefits are also discussed.
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影响因子：
16.1
作者：
Atukorale PU;Covarrubias G;Bauer L;Karathanasis E
通讯作者：
Karathanasis E
影响因子：
9.5
作者：
Di Francesco, Valentina;Gurgone, Danila;Decuzzi, Paolo
通讯作者：
Decuzzi, Paolo
使用针对凋亡巨噬细胞的双模态单光子发射计算机断层扫描/磁共振成像探针检测易损动脉粥样硬化斑块
影响因子：
9.5
作者：
Cheng, Dengfeng;Li, Xiao;Shi, Hongcheng
通讯作者：
Shi, Hongcheng
影响因子：
17.1
作者：
Kamaly, Nazila;Fredman, Gabrielle;Fojas, Jhalique Jane R.;Subramanian, Manikandan;Choi, Won Ii;Zepeda, Katherine;Vilos, Cristian;Yu, Mikyung;Gadde, Suresh;Wu, Jun;Milton, Jaclyn;Leitao, Renata Carvalho;Fernandes, Livia Rosa;Hasan, Moaraj;Gao, Huayi;Vance Nguyen;Harris, Jordan;Tabas, Ira;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.
影响因子：
14
作者：
Aviv, Hagit;Bartling, Sonke;Margel, Shlomo
通讯作者：
Margel, Shlomo