Proton pump inhibitors and the risk of pneumonia: a comparison of cohort and self-controlled case series designs.
Proton pump inhibitors and the risk of pneumonia: a comparison of cohort and self-controlled case series designs.
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DOI：
10.1186/1471-2288-13-82
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发表时间：
2013-06-24
影响因子：
4
通讯作者：
Roughead EE
中科院分区：
文献类型：
--
作者：
Ramsay EN;Pratt NL;Ryan P;Roughead EE
比较新使用者队列研究设计和自身对照病例系列（SCCS）设计的结果，使用分发质子泵抑制剂的患者与未暴露患者相比因肺炎住院的风险作为病例研究。使用了澳大利亚政府退伍军人事务部行政索赔数据库。在2007年7月1日至2011年6月30日的4年研究期间，确定了质子泵抑制剂暴露和因肺炎住院。两项研究采用相同的入选和排除标准，但SCCS研究纳入了至少有一次因肺炎住院的受试者。队列研究中纳入了105，467例受试者，SCCS中纳入了6775例受试者。两项研究均显示，与基线相比，在开始质子泵抑制剂治疗后的三个定义的风险期内，因肺炎住院的风险增加。前1 - 7天风险最高（队列RR，3.24; 95% CI（2.50，4.19）：SCCS：RR，3.07; 95% CI（2.69，3.50））。这项研究表明，当应用于质子泵抑制剂和肺炎的相关性时，自我对照病例系列方法产生的风险估计与新使用者队列研究设计相似。接触质子泵抑制剂会增加因肺炎住院的可能性，治疗第一周的风险最高。
To compare the results of a new-user cohort study design and the self-controlled case series (SCCS) design using the risk of hospitalisation for pneumonia in those dispensed proton pump inhibitors compared to those unexposed as a case study. The Australian Government Department of Veterans’ Affairs administrative claims database was used. Exposure to proton pump inhibitors and hospitalisations for pneumonia were identified over a 4 year study period 01 Jul 2007 -30 Jun 2011. The same inclusion and exclusion criteria were applied to both studies, however, the SCCS study included subjects with a least one hospitalisation for pneumonia. There were 105,467 subjects included in the cohort study and 6775 in the SCCS. Both studies showed an increased risk of hospitalisations for pneumonia in the three defined risk periods following initiation of proton pump inhibitors compared to baseline. With the highest risk in the first 1 to 7 days (Cohort RR, 3.24; 95% CI (2.50, 4.19): SCCS: RR, 3.07; 95% CI (2.69, 3.50)). This study has shown that the self-controlled case series method produces similar risk estimates to a new-users cohort study design when applied to the association of proton pump inhibitors and pneumonia. Exposure to a proton pump inhibitor increases the likelihood of being admitted to hospital for pneumonia, with the risk highest in the first week of treatment.
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影响因子：
14.6
作者：
Eom, Chun-Sick;Jeon, Christie Y.;Lee, Kang-Sook
通讯作者：
Lee, Kang-Sook
影响因子：
3
作者：
Sloan, KL;Sales, AE;Sharp, ND
通讯作者：
Sharp, ND
影响因子：
7.6
作者：
Laheij, RJF;Van Ijzendoorn, MC;Jansen, JBMJ
通讯作者：
Jansen, JBMJ
影响因子：
2.1
作者：
Farrington, C. Paddy;Whitaker, Heather J.;Hocine, Mounia N.
通讯作者：
Hocine, Mounia N.
影响因子：
--
作者：
Gulmez, Sinem Ezgi;Holm, Anette;Hallas, Jesper
通讯作者：
Hallas, Jesper