Nanoparticle-emitted light attenuates amyloid-β-induced superoxide and inflammation in astrocytes.
Nanoparticle-emitted light attenuates amyloid-β-induced superoxide and inflammation in astrocytes.
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DOI：
10.1016/j.nano.2013.10.007
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发表时间：
2014-01
影响因子：
5.4
通讯作者：
Lee, James C-M.
中科院分区：
文献类型：
--
作者：
Bungart, Brittani L.;Dong, Li;Sobek, Daniel;Sun, Grace Y.;Yao, Gang;Lee, James C-M.
Alzheimer’s disease (AD) is the sixth leading cause of age-related death with no effective intervention yet available. Our previous studies have demonstrated the potential efficacy of Low Level Laser Therapy (LLLT) in AD cell models by mitigating amyloid-β peptide (Aβ)-induced oxidative stress and inflammation. However, the penetration depth of light is still the major challenge for implementing LLLT in animal models and in the clinical settings. In this study, we present the potential of applying Bioluminescence Resonance Energy Transfer to Quantum Dots (BRET-Qdots) as an alternative near infrared (NIR) light source for LLLT. Our results show that BRET-Qdot-emitted NIR suppresses Aβ-induced oxidative stress and inflammatory responses in primary rat astrocytes. These data provide a proof of concept for a nanomedicine platform for LLLT.
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影响因子：
3.7
作者：
Haeussinger FB;Heinzel S;Hahn T;Schecklmann M;Ehlis AC;Fallgatter AJ
通讯作者：
Fallgatter AJ
神经血管功能障碍，炎症和内皮激活：对阿尔茨海默氏病的发病机理的影响。
影响因子：
9.3
作者：
Grammas P
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Grammas P
纳米颗粒的持续组织动力学和重新分布，量子点705，在小鼠中：ICP-MS定量评估。
影响因子：
10.4
作者：
Yang, Raymond S H;Chang, Louis W;Wu, Jui-Pin;Tsai, Ming-Hsien;Wang, Hsiu-Jen;Kuo, Yu-Chun;Yeh, Teng-Kuang;Yang, Chung Shi;Lin, Pinpin
通讯作者：
Lin, Pinpin
影响因子：
46.9
作者：
So, MK;Xu, CJ;Rao, JH
通讯作者：
Rao, JH
影响因子：
3.6
作者：
Lim, Jinhwan;Ali, Zeeshan M.;Watkins, John B., III
通讯作者：
Watkins, John B., III