Simulation of near-infrared light absorption considering individual head and prefrontal cortex anatomy: implications for optical neuroimaging.
Simulation of near-infrared light absorption considering individual head and prefrontal cortex anatomy: implications for optical neuroimaging.
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DOI：
10.1371/journal.pone.0026377
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Fallgatter AJ
中科院分区：
文献类型：
--
作者：
Haeussinger FB;Heinzel S;Hahn T;Schecklmann M;Ehlis AC;Fallgatter AJ
功能性近红外光谱（fNIRS）是一种已建立的光学神经成像方法，用于测量功能性血液动力学反应以推断神经激活。然而，个体解剖结构对fNIRS测量皮质灰质内血流动力学的灵敏度的影响仍然未知。通过Monte Carlo模拟和结构MRI的23名健康受试者（平均年龄：岁），我们的特点是个体分布的组织特异性近红外光吸收下24个前额叶fNIRS通道。因此，我们研究了头皮-皮质距离（SCD）、额窦体积以及脑沟形态对近红外光穿过的灰质体积（）的影响，即解剖学依赖的fNIRS灵敏度。光极间的近红外光吸收分布为一个旋转椭球体，其平均穿透深度考虑光的最深处。对探测到的光子包头皮和骨骼吸收和吸收的能量。平均体积与SCD和额窦体积呈负相关（），额窦相对较大的受试者的平均体积比较小的受试者的平均体积小。头围与平均SCD（）和经额窦体积（）显著正相关。脑沟形态学对。我们的研究结果表明，考虑个人SCD和额窦体积的解剖因素影响fNIRS的灵敏度。头围可以代表部分控制这些误差方差来源的实际测量。
Functional near-infrared spectroscopy (fNIRS) is an established optical neuroimaging method for measuring functional hemodynamic responses to infer neural activation. However, the impact of individual anatomy on the sensitivity of fNIRS measuring hemodynamics within cortical gray matter is still unknown. By means of Monte Carlo simulations and structural MRI of 23 healthy subjects (mean age: years), we characterized the individual distribution of tissue-specific NIR-light absorption underneath 24 prefrontal fNIRS channels. We, thereby, investigated the impact of scalp-cortex distance (SCD), frontal sinus volume as well as sulcal morphology on gray matter volumes () traversed by NIR-light, i.e. anatomy-dependent fNIRS sensitivity. The NIR-light absorption between optodes was distributed describing a rotational ellipsoid with a mean penetration depth of considering the deepest of light. Of the detected photon packages scalp and bone absorbed and absorbed of the energy. The mean volume was negatively correlated () with the SCD and frontal sinus volume () and was reduced by in subjects with relatively large compared to small frontal sinus. Head circumference was significantly positively correlated with the mean SCD () and the traversed frontal sinus volume (). Sulcal morphology had no significant impact on . Our findings suggest to consider individual SCD and frontal sinus volume as anatomical factors impacting fNIRS sensitivity. Head circumference may represent a practical measure to partly control for these sources of error variance.
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影响因子：
2.9
作者：
Linden, David E. J.;Fallgatter, Andreas J.
通讯作者：
Fallgatter, Andreas J.
影响因子：
5.7
作者：
Nenadic, Igor;Sauer, Heinrich;Gaser, Christian
通讯作者：
Gaser, Christian
DOI：
10.1073/pnas.85.14.4971
发表时间：
1988-07-01
影响因子：
11.1
作者：
CHANCE, B;LEIGH, JS;BORETSKY, R
通讯作者：
BORETSKY, R
影响因子：
1.4
作者：
Kim, S;Lee, JH
通讯作者：
Lee, JH
影响因子：
3.8
作者：
Lee, CK;Sun, CW;Hsieh, JC
通讯作者：
Hsieh, JC