Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing.
Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing.
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DOI：
10.3390/molecules25184073
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发表时间：
2020-09-07
期刊：
影响因子：
--
通讯作者：
Saso L
中科院分区：
文献类型：
--
作者：
Alam W;Khan H;Shah MA;Cauli O;Saso L
炎症是对由于物理、化学或机械创伤引起的不同病理、细胞或血管损伤的生理反应。它的特点是疼痛，发红，发热和肿胀。目前的天然药物被仔细选择作为一种新的治疗策略，用于管理炎症性疾病。天然产品中存在不同的植物化学成分。这些植物化学物质在体内和体外都具有很高的功效。其中，黄酮类化合物存在于许多食物，蔬菜和草药中，被认为是最活跃的成分，具有减轻炎症的能力。山奈酚是一种多酚，富含于水果、蔬菜和草药中。它也存在于植物源性饮料中。山奈酚被用于各种疾病的管理，但没有可用的综述文章可以总结所有的天然来源和生物活性，特别关注山奈酚的抗炎作用。因此，这篇文章的目的是提供一个简短的更新有关的文献综述山奈酚的抗炎作用及其可能的分子作用机制。此外，本文还对山奈酚的天然来源、化学性质、生物合成、口服吸收、代谢、生物利用度和治疗作用等方面的最新研究进展进行了综述。
Inflammation is a physiological response to different pathological, cellular or vascular damages due to physical, chemical or mechanical trauma. It is characterized by pain, redness, heat and swelling. Current natural drugs are carefully chosen as a novel therapeutic strategy for the management of inflammatory diseases. Different phytochemical constituents are present in natural products. These phytochemicals have high efficacy both in vivo and in vitro. Among them, flavonoids occur in many foods, vegetables and herbal medicines and are considered as the most active constituent, having the ability to attenuate inflammation. Kaempferol is a polyphenol that is richly found in fruits, vegetables and herbal medicines. It is also found in plant-derived beverages. Kaempferol is used in the management of various ailments but there is no available review article that can summarize all the natural sources and biological activities specifically focusing on the anti-inflammatory effect of kaempferol. Therefore, this article is aimed at providing a brief updated review of the literature regarding the anti-inflammatory effect of kaempferol and its possible molecular mechanisms of action. Furthermore, the review provides the available updated literature regarding the natural sources, chemistry, biosynthesis, oral absorption, metabolism, bioavailability and therapeutic effect of kaempferol.
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影响因子：
1.9
作者：
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通讯作者：
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影响因子：
6.1
作者：
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影响因子：
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作者：
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影响因子：
4.5
作者：
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影响因子：
3.6
作者：
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通讯作者：
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