Association of sleep quality before and after SARS-CoV-2 infection with clinical outcomes in hospitalized patients with COVID-19 in China.
Association of sleep quality before and after SARS-CoV-2 infection with clinical outcomes in hospitalized patients with COVID-19 in China.
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DOI：
10.17179/excli2021-3451
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发表时间：
2021
期刊：
影响因子：
4.6
通讯作者：
Bao W
中科院分区：
文献类型：
--
作者：
Zhang L;Li T;Chen L;Wu F;Xia W;Huang M;Guo Z;Song L;Yin H;Zhang Y;Yu Y;Cai S;Lu Z;Rong S;Bao W
睡眠被认为有助于宿主防御病原体。我们的目的是调查新冠肺炎住院患者的睡眠质量与临床结果的关系。我们对205名确诊为中度新冠肺炎的成人住院患者进行了前瞻性队列研究，并进行了随访，直到出院或死亡。匹兹堡睡眠质量指数(PSQI)评估感染前后的睡眠质量。主要结果是重症或危重肺炎的发生率，次要结果是住院时间和随访期间的实验室测量。在纳入的205例住院患者中，185例(90.2%)感染后睡眠质量较感染前差，25例(12.2%)在随访期间发展为重症或危重肺炎。在COX回归模型中，感染前后PSQI评分每增加1分，发生重症肺炎的调整风险比分别为1.23(95%CI：1.09，1.39)和1.35(95%CI：1.08，1.67)。睡眠质量较差也与住院时间延长和几个实验室标记表明的更严重的免疫系统失调显著相关。睡眠质量较差，无论是在日常时间还是在感染SARS-CoV-2后，都与较差的临床结果相关。这些发现突显了良好睡眠在应对新近流行的新冠肺炎方面的重要性。
Sleep is believed to benefit the host defense against pathogens. We aimed to investigate the association of sleep quality with clinical outcomes among hospitalized patients with COVID-19. We conducted a prospective cohort study in 205 adult hospitalized patients with diagnosed moderate COVID-19, with follow-up until hospital discharge or death. Pittsburgh Sleep Quality Index (PSQI) assessed sleep quality before and after infection. The primary outcome was the incidence of severe or critical pneumonia, and the secondary outcomes were duration of hospital stay and laboratory measurements during the follow up. Among the 205 included hospitalized patients, 185 (90.2 %) experienced poorer sleep quality after infection than before according to the PSQI score, and 25 (12.2 %) developed severe or critical pneumonia during follow-up. In Cox regression models, the adjusted hazard ratio of developing severe or critical pneumonia associated with each 1 score increment in the PSQI score before and after infection was 1.23 (95% CI: 1.09, 1.39) and 1.35 (95 % CI: 1.08, 1.67), respectively. Poorer sleep quality was also significantly associated with a prolonged hospital stay and more serious dysregulations in immune system indicated by several laboratory markers. Poorer sleep quality, either in the daily time or after infection with SARS-CoV-2, was associated with worse clinical outcomes. These findings highlight the importance of good sleep in confronting the emerging pandemic of COVID-19.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
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影响因子：
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影响因子：
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作者：
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