Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.
Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.
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DOI：
10.1038/s41598-018-26096-y
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发表时间：
2018-05-17
影响因子：
4.6
通讯作者：
Emir UE
中科院分区：
文献类型：
--
作者：
Steel A;Chiew M;Jezzard P;Voets NL;Plaha P;Thomas MA;Stagg CJ;Emir UE
磁共振波谱成像（MRSI）是一种有前途的技术，在实验和临床设置。然而，到目前为止，MRSI已经阻碍了过长的采集时间和伪影所造成的受试者运动和硬件相关的频率漂移。在本研究中，我们证明了密度加权同心环轨迹（DW-CRT）k空间采样与半激光激发和代谢循环相结合，使高分辨率MRSI数据能够在3特斯拉快速采集。使用该方法在13分30秒内以5 × 5 mm的平面内分辨率从6名健康志愿者获得单层全强度MRSI数据（短回波时间（TE）半激光TE = 32 ms）。使用LC模型分析，我们发现获得的光谱允许总N-乙酰天冬氨酸（中位数Cramer-Rao下限[CRLB] = 3%）、谷氨酸+谷氨酰胺（8%）和谷胱甘肽（13%）的图谱。此外，我们通过优化TE来检测2-羟基戊二酸（长TE半激光，TE = 110 ms），以在单个患者中产生III级IDH突变型少突胶质细胞瘤的相关高分辨率代谢物图谱，从而证明了该技术的潜在临床实用性。本研究证明了MRSI在3 T临床环境中的潜在效用。
Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla. Single-slice full-intensity MRSI data (short echo time (TE) semi-LASER TE = 32 ms) were acquired from 6 healthy volunteers with an in-plane resolution of 5 × 5 mm in 13 min 30 sec using this approach. Using LCModel analysis, we found that the acquired spectra allowed for the mapping of total N-acetylaspartate (median Cramer-Rao Lower Bound [CRLB] = 3%), glutamate+glutamine (8%), and glutathione (13%). In addition, we demonstrate potential clinical utility of this technique by optimizing the TE to detect 2-hydroxyglutarate (long TE semi-LASER, TE = 110 ms), to produce relevant high-resolution metabolite maps of grade III IDH-mutant oligodendroglioma in a single patient. This study demonstrates the potential utility of MRSI in the clinical setting at 3 Tesla.
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影响因子：
3.3
作者：
Jiang, Wenwen;Lustig, Michael;Larson, Peder E. Z.
通讯作者：
Larson, Peder E. Z.
影响因子：
3.3
作者：
Adalsteinsson, E;Irarrazabal, P;Spielman, DM
通讯作者：
Spielman, DM
影响因子：
11.2
作者：
Emir UE;Larkin SJ;de Pennington N;Voets N;Plaha P;Stacey R;Al-Qahtani K;Mccullagh J;Schofield CJ;Clare S;Jezzard P;Cadoux-Hudson T;Ansorge O
通讯作者：
Ansorge O
影响因子：
3.3
作者：
KLOSE, U
通讯作者：
KLOSE, U
影响因子：
3.3
作者：
Greiser, A;von Kienlin, M
通讯作者：
von Kienlin, M