Efficacy of a skeletal muscle-powered dynamic patch: Part 1. Left ventricular assistance.

Efficacy of a skeletal muscle-powered dynamic patch: Part 1. Left ventricular assistance.
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骨骼肌驱动的动态贴片的功效:第 1 部分。左心室辅助。

DOI:
10.1016/0003-4975(94)00528-f
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发表时间:
1995
期刊:
The Annals of thoracic surgery
影响因子:
--
通讯作者:
Y. Watanabe
Y. Watanabe
中科院分区:
--
文献类型:
--
作者:
M. Takahashi;T. Misaki;G. Watanabe;H. Ohtake;Y. Tsunezuka;M. Wada;N. Sakakibara;Y. Matsunaga;M. Kawasuji;Y. Watanabe

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在这项研究中,我们研究了骨骼肌动力,动态补丁提供左心室援助的能力。利用背阔肌提供的线性牵引力和液体作为动力传递介质,研制了一种驱动器。切开肌肉的近端部分,并重新连接到驱动器上。在体外循环过程中切除左心室心尖部,植入衬有自体心包的动态补片。本文对8只犬体外循环脱机后的血流动力学进行了研究。发现肌肉刺激显著增加主动脉收缩压(91.6对112.1 mm Hg; p < 0.01)、平均主动脉压(65.2对73.0 mm Hg; p < 0.01)和主动脉血流量(0.77对0.92 L/min; p < 0.01)。左房压从17.9 mmHg降至16.6 mmHg(P < 0.01)。这种“混合型”左心室辅助装置具有显著的辅助循环效果,具有显著的临床优势。使用预处理骨骼肌的进一步实验研究是必要的,以评估这种技术的长期影响。
In this study, we examined the capability of a skeletal muscle—powered, dynamic patch to provide left ventricular assistance. An actuator was developed that used linear traction power furnished by the latissimus dorsi muscle and liquid as the medium for power transfer. The proximal portion of the muscle was dissected and was reattached to the actuator. The left ventricular apex was excised, and the dynamic patch lined with autologous pericardium was implanted during cardiopulmonary bypass. Hemodynamic studies were performed in 8 dogs after weaning from cardiopulmonary bypass. Muscle stimulation was found to significantly increase the systolic aortic pressure (91.6 versus 112.1 mm Hg; p < 0.01), the mean aortic pressure (65.2 versus 73.0 mm Hg; p < 0.01), and aortic blood flow (0.77 versus 0.92 L/min; p < 0.01). The left atrial pressure decreased from 17.9 to 16.6 mm Hg (p < 0.01). This “hybrid” left ventricular assist device possesses notable clinical advantages because of its remarkable efficacy in assisting circulation. Further experimental studies using preconditioned skeletal muscle are necessary to assess the long-term effects of this technique.
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DOI: 10.1016/0003-4975(92)91392-m
发表时间: 1992
期刊: The Annals of thoracic surgery
影响因子: --
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DOI: --
发表时间: 1982
期刊: Transactions - American Society for Artificial Internal Organs
影响因子: --
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通讯作者: Buckley,MJ
DOI: --
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期刊: Circulation
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DOI: --
发表时间: 1992
期刊: The Journal of thoracic and cardiovascular surgery
影响因子: --
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