Modeling Alzheimer's disease in transgenic rats.
Modeling Alzheimer's disease in transgenic rats.
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DOI：
10.1186/1750-1326-8-37
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发表时间：
2013-10-25
影响因子：
15.1
通讯作者：
Cuello AC
中科院分区：
文献类型：
--
作者：
Do Carmo S;Cuello AC
阿尔茨海默病(AD)是痴呆症最常见的形式。在诊断阶段，阿尔茨海默病的特点是细胞外淀粉样斑块积聚、细胞内神经原纤维缠结和神经元丢失。尽管治疗方法多种多样，但这种情况仍然无法治愈，因为在临床诊断时，大脑已经遭受了不可逆转的广泛损害。近年来，阿尔茨海默病在临床表现前几十年就开始出现，这一点已变得明显。在这方面，转基因动物模型可以揭示这一“临床前”阶段的潜在机制，使识别和验证新的治疗靶点成为可能。本文总结了在大鼠体内建立模拟AD病理各方面的模型所作的巨大努力。转基因大鼠模型提供了比小鼠独特的优势。老鼠在生理上、基因上和形态上都更接近人类。更重要的是，老鼠有一个很好的特征，丰富的行为展示。因此，AD的大鼠模型应该可以更复杂和准确地评估病理和新的治疗方法对认知结果的影响。
Alzheimer’s disease (AD) is the most common form of dementia. At the diagnostic stage, the AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular neurofibrillary tangles and neuronal loss. Despite the large variety of therapeutic approaches, this condition remains incurable, since at the time of clinical diagnosis, the brain has already suffered irreversible and extensive damage. In recent years, it has become evident that AD starts decades prior to its clinical presentation. In this regard, transgenic animal models can shed much light on the mechanisms underlying this “pre-clinical” stage, enabling the identification and validation of new therapeutic targets. This paper summarizes the formidable efforts to create models mimicking the various aspects of AD pathology in the rat. Transgenic rat models offer distinctive advantages over mice. Rats are physiologically, genetically and morphologically closer to humans. More importantly, the rat has a well-characterized, rich behavioral display. Consequently, rat models of AD should allow a more sophisticated and accurate assessment of the impact of pathology and novel therapeutics on cognitive outcomes.
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DOI：
10.1016/s0006-291x(84)80190-4
发表时间：
1984-01-01
影响因子：
3.1
作者：
GLENNER, GG;WONG, CW
通讯作者：
WONG, CW
DOI：
10.1016/s0169-328x(99)00157-6
发表时间：
1999-10-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Grant, SM;Morinville, A;Cuello, AC
通讯作者：
Cuello, AC
影响因子：
4.2
作者：
Filipcik, Peter;Zilka, Norbert;Novak, Michal
通讯作者：
Novak, Michal
影响因子：
9.3
作者：
Giacobini, E
通讯作者：
Giacobini, E
影响因子：
3.3
作者：
Echeverria, V;Ducatenzeiler, A;Cuello, AC
通讯作者：
Cuello, AC