Aortic relative pressure components derived from four-dimensional flow cardiovascular magnetic resonance.
Aortic relative pressure components derived from four-dimensional flow cardiovascular magnetic resonance.
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DOI：
10.1002/mrm.25015
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发表时间：
2014-10
影响因子：
3.3
通讯作者：
Smith, Nicolas P.
中科院分区：
文献类型：
--
作者：
Lamata, Pablo;Pitcher, Alex;Krittian, Sebastian;Nordsletten, David;Bissell, Malenka M.;Cassar, Thomas;Barker, Alex J.;Markl, Michael;Neubauer, Stefan;Smith, Nicolas P.
关键词：
描述相对主动脉压时空分布的评估，量化其三个主要分量的大小。9名健康志愿者和3名主动脉疾病患者（二叶式主动脉瓣、夹层和马凡综合征）接受了4D-flow CMR。通过求解压力泊松方程，计算了CMR流场的时空压力图。压力的各个分量被分成随时间变化的惯性分量（“瞬态”）、随空间变化的惯性分量（“对流”）和粘性分量。相对主动脉压主要由瞬时效应引起，随后是对流和小粘性贡献（在健康受试者中分别为64.5、13.6和0.3 mmHg/m），尽管区域分析显示在特定情况下普遍存在对流效应，例如，主动脉窦和主动脉弓在峰值速度的瞬间。患者表现出峰值瞬态值和持续时间的差异，局部突然对流变化可由主动脉几何结构异常解释，包括存在动脉瘤、假性缩窄、夹层入口或复杂的血流模式。相对压力的三个组成部分的评价，使量化的机械信息的理解和分层的主动脉疾病，指导治疗的潜在未来的影响。Magn Reson Med 72：1162-1169，2014.© 2013作者。《医学中的磁共振》（Magnetic Resonance in Medicine），Wiley Periodicals，Inc.出版。国际医学磁共振学会（International Society for Magnetic Resonance in Medicine）这是一个开放获取的条款下的知识共享署名许可证，允许使用，分发和复制在任何媒体上，只要原始作品是适当的引用。
To describe the assessment of the spatiotemporal distribution of relative aortic pressure quantifying the magnitude of its three major components. Nine healthy volunteers and three patients with aortic disease (bicuspid aortic valve, dissection, and Marfan syndrome) underwent 4D-flow CMR. Spatiotemporal pressure maps were computed from the CMR flow fields solving the pressure Poisson equation. The individual components of pressure were separated into time-varying inertial (“transient”), spatially varying inertial (“convective”), and viscous components. Relative aortic pressure is primarily caused by transient effects followed by the convective and small viscous contributions (64.5, 13.6, and 0.3 mmHg/m, respectively, in healthy subjects), although regional analysis revealed prevalent convective effects in specific contexts, e.g., Sinus of Valsalva and aortic arch at instants of peak velocity. Patients showed differences in peak transient values and duration, and localized abrupt convective changes explained by abnormalities in aortic geometry, including the presence of an aneurysm, a pseudo-coarctation, the inlet of a dissection, or by complex flow patterns. The evaluation of the three components of relative pressure enables the quantification of mechanistic information for understanding and stratifying aortic disease, with potential future implications for guiding therapy. Magn Reson Med 72:1162–1169, 2014. © 2013 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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影响因子：
3.3
作者：
Bock, Jelena;Frydrychowicz, Alex;Markl, Michael
通讯作者：
Markl, Michael
影响因子：
4.4
作者：
Ebbers, Tino;Farneback, Gunnar
通讯作者：
Farneback, Gunnar
DOI：
10.1016/s0735-1097(00)00963-3
发表时间：
2000-11-15
影响因子：
24
作者：
Firstenberg, MS;Vandervoort, PM;Thomas, JD
通讯作者：
Thomas, JD
影响因子：
4.4
作者：
Markl, Michael;Harloff, Andreas;Frydrychowicz, Alex
通讯作者：
Frydrychowicz, Alex
影响因子：
9.6
作者：
Anjum, A.;von Allmen, R.;Powell, J. T.
通讯作者：
Powell, J. T.