Analytical and numerical modeling of the hearing system: Advances towards the assessment of hearing damage.

Analytical and numerical modeling of the hearing system: Advances towards the assessment of hearing damage.
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DOI:
10.1016/j.heares.2017.01.015
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发表时间:
2017-06
期刊:
影响因子:
2.8
通讯作者:
Cardoso L
Cardoso L
中科院分区:
医学1区
文献类型:
--
作者:
De Paolis A;Bikson M;Nelson JT;de Ru JA;Packer M;Cardoso L

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听力是一种极其复杂的现象,涉及大量相互关联的变量,这些变量在活体中难以测量。为了在简化且可控的条件下研究这一过程,经过数十年的研究,声音传播模型得以建立。建立听力系统模型的价值不仅在于解释听力系统的正常功能以及解释实验和临床观察结果,还在于模拟导致听力损伤和听力损失的各种病理状况,以及用于研发听觉植入物、有效的耳部保护装置和听觉危害应对措施。在本文中,我们综述了用于对外耳、中耳、内耳的听觉功能以及柯蒂氏器的微力学进行建模的策略,以及从这些建模工作中获得的一些关键成果。近期的分析和数值方法已将一些参数和结构的非线性行为纳入其模型中。完整听力系统的模型很少;特别是,我们描述了人类听觉危害评估算法(AHAAH)模型的演变,该模型用于预测高强度声压导致的听力损伤。与AHAAH模型不同,整个听力系统的三维有限元模型尚无法预测听觉风险和阈值偏移,预计AHAAH模型和有限元模型都将朝着在各种刺激条件和病理状况下更准确地评估阈值偏移和听力损失的方向发展。
Hearing is an extremely complex phenomenon, involving a large number of interrelated variables that are difficult to measure in vivo. In order to investigate such process under simplified and well-controlled conditions, models of sound transmission have been developed through many decades of research. The value of modeling the hearing system is not only to explain the normal function of the hearing system and account for experimental and clinical observations, but to simulate a variety of pathological conditions that lead to hearing damage and hearing loss, as well as for development of auditory implants, effective ear protections and auditory hazard countermeasures. In this paper, we provide a review of the strategies used to model the auditory function of the external, middle, inner ear, and the micromechanics of the organ of Corti, along with some of the key results obtained from such modeling efforts. Recent analytical and numerical approaches have incorporated the nonlinear behavior of some parameters and structures into their models. Few models of the integrated hearing system exist; in particular, we describe the evolution of the Auditory Hazard Assessment Algorithm for Human (AHAAH) model, used for prediction of hearing damage due to high intensity sound pressure. Unlike the AHAAH model, 3D finite element models of the entire hearing system are not able yet to predict auditory risk and threshold shifts, it is expected that both AHAAH and FE models would evolve towards a more accurate assessment of threshold shifts and hearing loss under a variety of stimuli conditions and pathologies.
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