Anti-inflammatory effect of rosuvastatin decreases alveolar bone loss in experimental periodontitis.
Anti-inflammatory effect of rosuvastatin decreases alveolar bone loss in experimental periodontitis.
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瑞舒伐他汀的抗炎作用可减少实验性牙周炎中的牙槽骨丢失。
作者：
F. Kırzıoğlu;Memduha Tözüm Bulut;B. Doğan;Ö. Fentoğlu;Ö. Özmen;S. A. Çarsancaklı;Aysel Ergün;M. Özdem;H. Orhan
研究了全身给予瑞舒伐他汀对结扎性牙周炎大鼠牙槽骨丢失（ABL）、细胞因子水平和氧化状态的影响。将大鼠随机分为四组：未结扎组(C)；非结扎+瑞舒伐他汀组(R)；结扎组(P)；结扎+瑞舒伐他汀组（PR）。上颌第二磨牙结扎，瑞舒伐他汀治疗14天。在大鼠安乐死后，进行组织形态学和组织学分析，并采用酶联免疫吸附法测定血清白细胞介素(IL)-1β、IL-10水平以及氧化和抗氧化参数（丙二醛[MDA]、超氧化物歧化酶、谷胱甘肽和谷胱甘肽过氧化物酶）。瑞舒伐他汀显著降低牙周炎ABL、炎症浸润和破骨细胞的程度，但增加成骨细胞的数量。虽然瑞舒伐他汀降低了IL-1β水平，但PR组和P组之间没有显著差异。PR组不仅IL-10水平显著高于P组，IL-1β / IL-10比值也低于P组。P组MDA水平明显高于C组，PR组与C组间差异不显著。本研究提示瑞舒伐他汀可降低结扎性牙周炎患者的ABL，且其抗炎作用比抗氧化作用更显著。
The effects of systemically administered rosuvastatin on alveolar bone loss (ABL), cytokine levels and oxidative status were investigated in rats with ligature-induced periodontitis. Rats were divided randomly into four groups: a non-ligated group (C); a non-ligated+rosuvastatin group (R); a ligated group (P); and a ligated+rosuvastatin group (PR). Ligatures were placed at the maxillary second molars, and rosuvastatin was administered for 14 days. After the rats had been euthanatized, histomorphometric and histological analyses were performed, and the serum levels of interleukin (IL)-1β, IL-10 and oxidant and antioxidant parameters (malondialdehyde [MDA], superoxide dismutase, glutathione, and glutathione peroxidase) were evaluted by enzyme-linked immunosorbent assay. Rosuvastatin significantly decreased the extent of ABL, inflammatory infiltration and osteoclasts in periodontitis, but increased the numbers of osteoblasts. Although rosuvastatin reduced the levels of IL-1β, they did not differ significantly between the PR and P groups. In the PR group, not only were IL-10 levels significantly higher but also the ratio of IL-1β to IL-10 was lower than in the P group. Although MDA levels were significantly increased in the P group relative to the C group, they did not differ significantly between the PR and C groups. The present data suggest that rosuvastatin decreases ABL in ligature-induced periodontitis, and that its anti-inflammatory effect is more remarkable than its antioxidant effect.
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