Hematoporphyrin derivative therapy of papillomas. Experimental study.
Hematoporphyrin derivative therapy of papillomas. Experimental study.
复制标题
血卟啉衍生物治疗乳头状瘤。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
A. Abramson
中科院分区：
文献类型：
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作者：
M. Shikowitz;B. Steinberg;A. Abramson
血卟啉衍生物已被证明选择性地定位于恶性组织和化学诱导的动物乳头状瘤。它是一种强大的光敏剂，当被适当波长的光激活时（光动力疗法[PDT]），它可以通过产生单线态氧而导致组织的破坏和死亡。喉乳头状瘤是一种生长迅速的良性上皮性肿瘤，其临床过程以手术切除后多次复发为标志。在考虑PDT作为治疗这种使人衰弱的疾病的治疗方式之前，我们开发了一种用于实验的动物模型。使用棉尾兔乳头状瘤病毒，有时被称为肖普乳头状瘤病毒，大的皮肤乳头状瘤诱导荷兰皮带兔的背部。在静脉内施用血卟啉衍生物后，用白色光递送PDT。乳头状瘤明显消退，被正常的毛发皮肤替代。这项工作的控制喉乳头状瘤病的临床意义进行了讨论。
Hematoporphyrin derivative has been shown to selectively localize in malignant tissues and chemically induced animal papillomas. It is a powerful photo-sensitizing agent that can cause destruction and death of tissues in which it has localized by the generation of singlet oxygen when activated by light of the appropriate wavelength (photodynamic therapy [PDT]). Laryngeal papillomas are rapidly growing benign epithelial neoplasms with a clinical course marked by multiple recurrences after surgical removal. Before considering PDT as a therapeutic modality in the treatment of this debilitating disease we developed an animal model for experimentation. Using the cottontail rabbit papillomavirus, sometimes referred to as the Shope papillomavirus, large cutaneous papillomas were induced on the backs of Dutch Belted rabbits. Following intravenous administration of hematoporphyrin derivative, PDT was delivered with white light. Marked regression of the papillomas was noted with replacement by normal hair-bearing skin. The clinical implications of this work to the control of laryngeal papillomatosis is discussed.
影响因子：
9.6
作者：
D. Cortese;J. Kinsey
通讯作者：
D. Cortese;J. Kinsey