Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF.
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF.
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肺泡巨噬细胞从胎儿单核细胞中发展，这些单核细胞在生命的第一周通过GM-CSF分化为长寿命细胞。
DOI：
10.1084/jem.20131199
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发表时间：
2013-09-23
期刊：
影响因子：
--
通讯作者：
Lambrecht BN
中科院分区：
文献类型：
--
作者：
Guilliams M;De Kleer I;Henri S;Post S;Vanhoutte L;De Prijck S;Deswarte K;Malissen B;Hammad H;Lambrecht BN
肺泡巨噬细胞以GM-CSF依赖性的方式与胎儿单核细胞区分开，并在出生后几天内定居肺泡空间。
居住的巨噬细胞可以从循环的成年单核细胞或原始的蛋黄囊衍生的巨噬细胞中发展。稳态AMF池。出生后，F4/80HICD11BLO原始巨噬细胞和Ly6Chicd11BHi胎儿单核细胞依次殖民地围绕E12.5和E16.5殖民地。收养鉴定的胎儿单核细胞，而不是原始巨噬细胞作为AMF的主要前体。新生小鼠在一周的时间内通过定义的发育阶段获得了AMF表型，并且在短期短期内持续了三个月。治疗返回了AMF的发育数周，尽管所得的AMF表现出未成熟的表型。出生后不久就采用稳定表型的单核细胞来响应有指导的细胞因子，然后一生自我维护。
Alveolar macrophages differentiate from fetal monocytes in a GM-CSF–dependent fashion and colonize the alveolar space within a few days after birth. Tissue-resident macrophages can develop from circulating adult monocytes or from primitive yolk sac–derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is unknown. By performing BrdU labeling and parabiosis experiments in adult mice, we found that circulating monocytes contributed minimally to the steady-state AMF pool. Mature AMFs were undetectable before birth and only fully colonized the alveolar space by 3 d after birth. Before birth, F4/80hiCD11blo primitive macrophages and Ly6ChiCD11bhi fetal monocytes sequentially colonized the developing lung around E12.5 and E16.5, respectively. The first signs of AMF differentiation appeared around the saccular stage of lung development (E18.5). Adoptive transfer identified fetal monocytes, and not primitive macrophages, as the main precursors of AMFs. Fetal monocytes transferred to the lung of neonatal mice acquired an AMF phenotype via defined developmental stages over the course of one week, and persisted for at least three months. Early AMF commitment from fetal monocytes was absent in GM-CSF–deficient mice, whereas short-term perinatal intrapulmonary GM-CSF therapy rescued AMF development for weeks, although the resulting AMFs displayed an immature phenotype. This demonstrates that tissue-resident macrophages can also develop from fetal monocytes that adopt a stable phenotype shortly after birth in response to instructive cytokines, and then self-maintain throughout life.
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发表时间：
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影响因子：
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