The Multilayer Connectome of Caenorhabditis elegans.
The Multilayer Connectome of Caenorhabditis elegans.
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DOI：
10.1371/journal.pcbi.1005283
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发表时间：
2016-12
影响因子：
4.3
通讯作者：
Schafer WR
中科院分区：
文献类型：
--
作者：
Bentley B;Branicky R;Barnes CL;Chew YL;Yemini E;Bullmore ET;Vértes PE;Schafer WR
连接组学主要关注大脑中突触连接的映射;然而，已经确定突触外体积传递，特别是通过单胺和神经肽，对大脑功能也至关重要，并且主要发生在突触连接体之外。我们已经绘制了假定的单胺连接，以及神经肽连接的子集，在C。elegans基于新的和已发表的基因表达数据。单胺和神经肽网络表现出不同的拓扑性质，单胺网络显示出高度分散的星形结构，具有丰富的相互连接的广播中心，神经肽网络显示出更经常性的，高度聚集的拓扑结构。尽管突触外（或无线）和突触（或有线）的连接体之间的重叠程度低，我们发现非常显着的多链接图案的相互作用，精确定位在网络中的胺能和神经肽信号调节突触活动的位置。因此，C. elegans连接体可以被映射为具有突触、间隙连接和神经调质层的多重网络，所述神经调质层代表神经元之间的交互的替代模式。这提供了一个新的拓扑计划，了解胺能和肽能调制的行为是如何实现的特定图案和位点的整合之间的硬连线突触或交界电路和突触外信号无线广播从少量的调制神经元。连接组学代表了在单个神经元及其突触连接水平上绘制大脑结构的努力。然而，神经回路也依赖于神经元之间的其他类型的信号传导，例如单胺和肽的突触外调制。在这里，我们提出了一个草案单胺连接体，沿着部分神经肽连接体，线虫C。elegans，基于新的和已发表的生物合成基因和受体的表达数据。我们描述了这些“无线”网络的结构特性，包括它们的拓扑特征和与有线突触和间隙连接连接体的相互作用模式。C.秀丽线虫可以作为理解包括人脑在内的大型神经系统的多重网络的原型。
Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function and occurs primarily outside the synaptic connectome. We have mapped the putative monoamine connections, as well as a subset of neuropeptide connections, in C. elegans based on new and published gene expression data. The monoamine and neuropeptide networks exhibit distinct topological properties, with the monoamine network displaying a highly disassortative star-like structure with a rich-club of interconnected broadcasting hubs, and the neuropeptide network showing a more recurrent, highly clustered topology. Despite the low degree of overlap between the extrasynaptic (or wireless) and synaptic (or wired) connectomes, we find highly significant multilink motifs of interaction, pinpointing locations in the network where aminergic and neuropeptide signalling modulate synaptic activity. Thus, the C. elegans connectome can be mapped as a multiplex network with synaptic, gap junction, and neuromodulator layers representing alternative modes of interaction between neurons. This provides a new topological plan for understanding how aminergic and peptidergic modulation of behaviour is achieved by specific motifs and loci of integration between hard-wired synaptic or junctional circuits and extrasynaptic signals wirelessly broadcast from a small number of modulatory neurons. Connectomics represents an effort to map brain structure at the level of individual neurons and their synaptic connections. However, neural circuits also depend on other types of signalling between neurons, such as extrasynaptic modulation by monoamines and peptides. Here we present a draft monoamine connectome, along with a partial neuropeptide connectome, for the nematode C. elegans, based on new and published expression data for biosynthetic genes and receptors. We describe the structural properties of these "wireless" networks, including their topological features and modes of interaction with the wired synaptic and gap junction connectomes. This multilayer connectome of C. elegans can serve as a prototype for understanding the multiplex networks comprising larger nervous systems, including the human brain.
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影响因子：
9.8
作者：
Donnelly JL;Clark CM;Leifer AM;Pirri JK;Haburcak M;Francis MM;Samuel AD;Alkema MJ
通讯作者：
Alkema MJ
DOI：
10.1523/jneurosci.0378-08.2008
发表时间：
2008-07-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dittman JS;Kaplan JM
通讯作者：
Kaplan JM
影响因子：
2.4
作者：
Bounova, Gergana;de Weck, Olivier
通讯作者：
de Weck, Olivier
影响因子：
56.9
作者：
Barabási, AL;Albert, R
通讯作者：
Albert, R
DOI：
10.1073/pnas.0409009101
发表时间：
2005-03-01
影响因子：
11.1
作者：
Gray, JM;Hill, JJ;Bargmann, CI
通讯作者：
Bargmann, CI