Monoaminergic orchestration of motor programs in a complex C. elegans behavior.
Monoaminergic orchestration of motor programs in a complex C. elegans behavior.
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DOI：
10.1371/journal.pbio.1001529
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发表时间：
2013
期刊：
影响因子：
9.8
通讯作者：
Alkema MJ
中科院分区：
文献类型：
--
作者：
Donnelly JL;Clark CM;Leifer AM;Pirri JK;Haburcak M;Francis MM;Samuel AD;Alkema MJ
单个单胺可以通过不同类别受体的突触和突触外激活来协调秀丽隐杆线虫复合运动序列的不同阶段。一元胺提供行为状态的化学代码。然而，人们对单胺能行为协调的神经机制知之甚少。触摸会引起秀丽隐杆线虫的逃避反应，动物向后移动并转身改变其运动方向。我们发现酪胺受体 SER-2 通过 Gαo 途径发挥作用，抑制突触到腹侧体壁肌肉的 GABA 能运动神经元释放神经递质。 SER-2 的突触外激活促进腹侧体壁肌肉收缩，从而导致腹侧紧密转动，从而使动物能够远离威胁性刺激。酪胺通过快速作用的离子型受体 LGC-55 的突触激活和慢速代谢型受体 SER-2 的突触外激活，在时间上协调逃避反应的不同阶段。我们的研究表明，在单细胞水平上，感觉输入如何招募单胺的作用来改变神经回路特性并协调复合运动序列。几十年来，神经系统如何控制复杂的行为一直引起神经生物学家的兴趣。有许多例子详细描述了特定行为的顺序运动模式。然而，人们对编排完整行为序列的神经机制知之甚少。轻轻触摸线虫的头部会引发逃避反应，动物会迅速向后移动。逆转之后是深度转向，使动物能够改变其运动方向并远离威胁性刺激。我们发现神经递质酪胺通过激活快速作用的离子通道来控制逃逸反应的初始逆转阶段，并通过激活慢速作用的 G 蛋白偶联受体 (GPCR) 来控制逃逸反应的后期逆转阶段。我们发现这种酪胺 GPCR 在与动物腹侧肌肉接触的神经元中表达。该受体的激活促进腹侧肌肉的收缩，从而允许动物在逃跑过程中转向并恢复相反方向的运动。我们的研究表明，单个神经递质如何通过激活不同类别的受体来协调复杂行为的连续阶段。
A single monoamine can orchestrate different phases of a compound motor sequence in C. elegans through the synaptic and extra-synaptic activation of distinct classes of receptors. Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the animal moves backward and turns to change its direction of locomotion. We show that the tyramine receptor SER-2 acts through a Gαo pathway to inhibit neurotransmitter release from GABAergic motor neurons that synapse onto ventral body wall muscles. Extrasynaptic activation of SER-2 facilitates ventral body wall muscle contraction, contributing to the tight ventral turn that allows the animal to navigate away from a threatening stimulus. Tyramine temporally coordinates the different phases of the escape response through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynaptic activation of the slow-acting metabotropic receptor, SER-2. Our studies show, at the level of single cells, how a sensory input recruits the action of a monoamine to change neural circuit properties and orchestrate a compound motor sequence. How the nervous system controls complex behaviors has intrigued neurobiologists for decades. There are many examples where sequential motor patterns of specific behaviors have been described in great detail. However, the neural mechanisms that orchestrate a full behavioral sequence are poorly understood. Gentle touch to the head of the roundworm C. elegans elicits an escape response in which the animal quickly moves backward. The reversal is followed by a deep turn that allows the animal to change its direction of locomotion and move away from the threatening stimulus. We found that the neurotransmitter tyramine controls the initial reversal phase of the escape response through the activation of a fast-acting ion channel and the later turning phase through the activation of a slow-acting G-protein coupled receptor (GPCR). We show that this tyramine GPCR is expressed in neurons that make contacts with the ventral muscles of the animal. Activation of this receptor facilitates the contraction of ventral muscles and thus allows the animal to turn and resume locomotion in the opposite direction during its escape. Our studies show how a single neurotransmitter coordinates sequential phases of a complex behavior through the activation of distinct classes of receptors.
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影响因子：
48
作者：
Guo, Zengcai V.;Hart, Anne C.;Ramanathan, Sharad
通讯作者：
Ramanathan, Sharad
影响因子：
16.2
作者：
Brundage, L;Avery, L;Simon, MI
通讯作者：
Simon, MI
影响因子：
64.8
作者：
Bendesky, Andres;Tsunozaki, Makoto;Rockman, Matthew V.;Kruglyak, Leonid;Bargmann, Cornelia I.
通讯作者：
Bargmann, Cornelia I.
DOI：
10.1523/jneurosci.4585-08.2009
发表时间：
2009-02-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Harris GP;Hapiak VM;Wragg RT;Miller SB;Hughes LJ;Hobson RJ;Steven R;Bamber B;Komuniecki RW
通讯作者：
Komuniecki RW
影响因子：
56.9
作者：
HORVITZ, HR;CHALFIE, M;EVANS, PD
通讯作者：
EVANS, PD