Effect of vascular radioactivity on regional values of cerebral blood flow: evaluation of methods for H(2)(15)O PET to distinguish cerebral perfusion from blood volume.
Effect of vascular radioactivity on regional values of cerebral blood flow: evaluation of methods for H(2)(15)O PET to distinguish cerebral perfusion from blood volume.
复制标题
血管放射性对脑血流量局部值的影响：评估 H(2)(15)O PET 区分脑灌注和血容量的方法。
DOI：
--
复制
发表时间：
2001
影响因子：
9.3
通讯作者：
Manouchehr Vafaee
中科院分区：
文献类型：
--
作者：
H. Okazawa;Manouchehr Vafaee
未标记的
UNLABELLED
To evaluate the appropriate model for calculating regional cerebral blood flow (rCBF) with PET and H(2)(15)O, the values obtained from 1- and 2-compartment analyses were compared.
METHODS
Dynamic PET scans were performed on 12 healthy volunteers after injection of H(2)(15)O in 2 conditions of baseline and visual stimulation. Calculation of rCBF was performed using the 2-weighted integral (WI) and autoradiographic methods for the 1-compartment analysis, and the 3-WI method was followed for the 2-compartment analysis. Arterial blood radioactivity was counted continuously and corrected for delay and dispersion. The rCBF images were transformed into the Talairach space and analyzed by statistical parametric mapping to identify regional differences in the 2 methods. The values obtained from regions of interest also were compared.
RESULTS
Although the difference in global CBF between the 2 models was not significant, rCBF values in the large arteries and neighbor areas were significantly greater in the 2-WI method than in the 3-WI method. However, regional differences in the activation studies were not affected when the 2 methods were compared. The images of cerebral arterial blood volume (V(0)) obtained by the 3-WI method showed a significant increase in V(0) in the visual cortex during visual stimulation.
CONCLUSION
These results suggest that the rCBF values in the 1-compartment analysis were affected by radioactivity in the vessels. The 3-WI method could provide rCBF values that are less influenced by vascular radioactivity and also show differences in V(0) in PET activation studies.
登录
查看更多内容
DOI：
--
发表时间：
1983-09
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通过对 H215O 组织活动的平均 PET 图像进行变化分布分析来绘制无创功能性脑图。
DOI：
--
发表时间：
1989
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Fox,PT;Mintun,MA
通讯作者：
Mintun,MA
影响因子：
2.5
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
使用切换范例改进 PET 激活研究中的信噪比。
DOI：
--
发表时间：
1995
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Cherry,SR;Woods,RP;Doshi,NK;Banerjee,PK;Mazziotta,JC
通讯作者：
Mazziotta,JC