Nitric oxide-dependent changes in Schistosoma mansoni gene expression.
Nitric oxide-dependent changes in Schistosoma mansoni gene expression.
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曼氏血吸虫基因表达的一氧化氮依赖性变化。
DOI：
10.1016/j.molbiopara.2006.08.003
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发表时间：
2006
影响因子：
1.5
通讯作者：
Greenberg,RobertM
中科院分区：
文献类型：
--
作者：
Messerli,ShantaM;Morgan,William;Birkeland,ShandaR;Bernier,Jeremiah;Cipriano,MichaelJ;McArthur,AndrewG;Greenberg,RobertM
Nitric oxide (NO)-related pathways potentially play at least two critical roles in schistosomes, the causative agents of schistosomiasis. First, these pathways may represent essential signaling cascades required for normal parasite physiology and survival. Second, NO-related pathways may also play an important role in parasite–host interactions. Several reports have demonstrated that platyhelminths have nitric oxide synthase (NOS) activity and that NO is likely acting as a signaling molecule in these organisms [1–4]. Furthermore, the host NO pathway may be involved in host defense against schistosome infection, though its precise role in vivo is not clear [5–7].Here we examine changes in parasite gene expression in response to exposure to exogenous NO in vitro. Prior studies have provided evidence of NO-related pathways in adult schistosomes [1, 2, 8]. However, the physiological role and downstream targets of NO have not been elucidated in adult worms. To assay NO-dependent changes in gene expression, we have used Long-SAGE (serial analysis of gene expression)[9], which provides both the identity of expressed genes and the relative levels of their expression.
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曼氏血吸虫：编码胞质铜/锌超氧化物歧化酶的基因的克隆和表征。
影响因子：
2.1
作者：
Mei,H;Hirai,H;Tanaka,M;Hong,Z;Rekosh,D;LoVerde,PT
通讯作者：
LoVerde,PT
影响因子：
4
作者：
MKOJI, GM;SMITH, JM;PRICHARD, RK
通讯作者：
PRICHARD, RK
影响因子：
2.1
作者：
A. Kohn;J. Lea;L. Moroz;R. Greenberg
通讯作者：
A. Kohn;J. Lea;L. Moroz;R. Greenberg
影响因子：
7
作者：
Stein, LD;Mungall, C;Lewis, S
通讯作者：
Lewis, S
影响因子：
3.1
作者：
James, SL;Cheever, AW;Wynn, TA
通讯作者：
Wynn, TA