Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2.
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2.
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DOI：
10.1126/sciimmunol.abl4509
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发表时间：
2021-10-15
影响因子：
24.8
通讯作者：
中科院分区：
文献类型：
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作者：
在小鼠模型中，疫苗接种或康复后对SARS-CoV-2的保护性免疫主要通过抗体反应来调节。SARS-CoV-2疫苗可以预防感染，但适应性免疫系统的各个组成部分在促进病毒清除和提供保护方面的相对重要性尚未得到很好的界定。伊斯雷洛等人。使用在呼吸道表达ACE2受体的小鼠来确定在初次感染期间SARS-CoV-2清除以及疫苗接种或康复后的保护所需的适应性免疫反应的细胞和体液效应器。在初次感染的情况下，适应性免疫反应对病毒清除至关重要，细胞或体液臂都可以促进病毒清除和提供保护。对SARS-CoV-2免疫或再感染后的保护性免疫主要以体液免疫为主。这些发现突显了新冠肺炎疫苗产生的抗体的重要性。严重急性呼吸综合征冠状病毒2(SARS-CoV-2)已在全球造成1.6亿多人感染和300多万人死亡。尽管目前正在部署有效的疫苗，但促进病毒清除和提供保护的适应性免疫决定因素仍然定义不清。利用SARS-CoV-2小鼠模型，我们证明了体液和细胞获得性免疫在初次感染的背景下有助于病毒清除。此外，我们发现，无论是恢复期的小鼠还是接受mRNA疫苗接种的小鼠，都能免受同源感染和受关注变种B.1.351的感染。此外，我们发现这种保护很大程度上是通过抗体反应而不是细胞免疫来调节的。这些结果突显了针对疫苗和自然感染产生的抗体在体内的保护能力。
In a mouse model, protective immunity to SARS-CoV-2 following vaccination or recovery is primarily mediated by the antibody response. SARS-CoV-2 vaccines protect against infection, but the relative importance of individual components of the adaptive immune system in promoting viral clearance and conferring protection is not well defined. Israelow et al. used mice expressing the ACE2 receptor in the respiratory tract to determine which cellular and humoral effectors of the adaptive immune response are required for SARS-CoV-2 clearance during primary infection and for protection after vaccination or convalescence. In the context of primary infection, the adaptive immune response was essential for viral clearance, and either the cellular or humoral arms could promote viral clearance and confer protection. Protective immunity to SARS-CoV-2 after vaccination or reinfection of convalescent mice was dominated by the humoral response. These findings highlight the importance of antibodies generated by COVID-19 vaccination. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160 million infections and more than 3 million deaths worldwide. Although effective vaccines are currently being deployed, the adaptive immune determinants that promote viral clearance and confer protection remain poorly defined. Using mouse models of SARS-CoV-2, we demonstrate that both humoral and cellular adaptive immunity contribute to viral clearance in the setting of primary infection. Furthermore, we find that either convalescent mice or mice that receive mRNA vaccination are protected from both homologous infection and infection with a variant of concern, B.1.351. In addition, we find that this protection is largely mediated by antibody response and not cellular immunity. These results highlight the in vivo protective capacity of antibodies generated to both vaccine and natural infection.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
9.2
作者：
Brocato RL;Kwilas SA;Kim RK;Zeng X;Principe LM;Smith JM;Hooper JW
通讯作者：
Hooper JW
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
DOI：
10.1056/nejmoa2034545
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
通讯作者：
Oxford University Hospitals Staff Testing Group
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group