Evaluation of the clinical relevance of anti-annexin-A5 antibodies in Chinese patients with antiphospholipid syndrome
Evaluation of the clinical relevance of anti-annexin-A5 antibodies in Chinese patients with antiphospholipid syndrome
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中国抗磷脂综合征患者抗膜联蛋白 A5 抗体的临床相关性评估
DOI：
10.1007/s10067-016-3510-8
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发表时间：
2017-02
影响因子：
3.4
通讯作者：
Li Yongzhe
中科院分区：
文献类型：
--
作者：
Zhang Shulan;Wu Ziyan;Li Jing;Wen Xiaoting;Li Liubing;Zhang Wen;Zhao Jiuliang;Zhang Fengchun;Li Yongzhe
抗磷脂综合征（APS）的一个标志性特征是存在抗磷脂抗体（aPL）。很少有研究涉及抗膜联蛋白A5抗体（aANXA 5）在中国APS患者中的临床相关性。在这项研究中，我们评估了aANXA 5诊断APS的临床性能。检测了313名受试者的血清，包括170名APS患者的血清，104名非APS疾病患者的血清作为疾病对照（DC），39名健康对照（HC）。通过ELISA测定血清IgG和IgM aANXA 5。总体而言，与DC和HC相比，原发性APS（PAPS）和与其他疾病相关的APS（APSAOD）患者的IgG和IgM aANXA 5水平均显著升高。IgG和IgM aANXA 5诊断APS的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为33.5%和15.3%、99.0%和99.0%、98.3%和96.3%、47.7%和41.7%。IgG aANXA 5与动脉血栓形成事件（OR，2.60; 95% CI，1.44-4.71）之间以及IgG aANXA 5与静脉血栓形成事件（OR，2.80; 95% CI，1.55-5.06）之间存在显著相关性。IgG或IgM aANXA 5与产科并发症之间没有相关性。我们的数据表明aANXA 5可以作为APS患者的诊断生物标志物。更重要的是，我们的数据强调了IgG aANXA 5在识别具有血栓形成高风险的APS患者中的潜在作用。
A hallmark feature of antiphospholipid syndrome (APS) is the presence of antiphospholipid antibodies (aPLs). Few studies have addressed the clinical relevance of anti-annexin A5 antibodies (aANXA5) in Chinese patients with APS. In this study, we evaluated the clinical performance of aANXA5 in the diagnosis of APS. Sera from 313 subjects were tested, including 170 samples from patients with APS, 104 samples from patients with non-APS diseases as disease controls (DC), and 39 healthy controls (HC). Serum IgG and IgM aANXA5 were determined by ELISA. Overall, the levels of both IgG and IgM aANXA5 were significantly increased in patients with primary APS (PAPS) and APS associated to other diseases (APSAOD) compared with DC and HC. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for IgG and IgM aANXA5 in the diagnosis of APS were 33.5 and 15.3, 99.0 and 99.0, 98.3 and 96.3, and 47.7 and 41.7%, respectively. Significant associations between IgG aANXA5 and arterial thrombotic events (OR, 2.60; 95% CI, 1.44–4.71) and between IgG aANXA5 and venous thrombotic events (OR, 2.80; 95% CI, 1.55–5.06) were identified. No correlations were identified between IgG or IgM aANXA5 and obstetric complications. Our data suggest that aANXA5 could serve as a diagnosis biomarker for patients with APS. More importantly, our data highlighted a potential role of IgG aANXA5 in identifying APS patients with high risk of thrombosis.
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DOI：
10.1016/s0021-9258(19)37128-5
发表时间：
1992-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Harry A M Andrees;Marc C. A. Stuart;Wim Th Hermenss;Chris P M Reutelingspergerll;H. Coenraad Hemkern;Peter M Frederikp;George M Willemss
通讯作者：
Harry A M Andrees;Marc C. A. Stuart;Wim Th Hermenss;Chris P M Reutelingspergerll;H. Coenraad Hemkern;Peter M Frederikp;George M Willemss
影响因子：
3.5
作者：
Ogawa, H;Zhao, DD;Triplett, DA
通讯作者：
Triplett, DA
DOI：
--
发表时间：
2000-04
期刊：
The Journal of rheumatology
影响因子：
--
作者：
G. Lakos;E. Kiss;N. Regéczy;P. Tarján;P. Soltész;M. Zeher;E. Bodolay;G. Szücs;S. Szakony;S. Sipka;G. Szegedi
通讯作者：
G. Lakos;E. Kiss;N. Regéczy;P. Tarján;P. Soltész;M. Zeher;E. Bodolay;G. Szücs;S. Szakony;S. Sipka;G. Szegedi
DOI：
10.1182/asheducation-2013.1.675
发表时间：
2013-12-01
影响因子：
3
作者：
Lim, Wendy
通讯作者：
Lim, Wendy
影响因子：
5.1
作者：
D. Erkan;M. Lockshin
通讯作者：
D. Erkan;M. Lockshin