Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection.

Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection.
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DOI:
10.1083/jcb.200904125
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发表时间:
2009-06-01
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Horsley V
Horsley V
中科院分区:
其他
文献类型:
--
作者:
Horsley V

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Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185:811–826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of β-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2.
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