TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection.
TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection.
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TXNIP通过抑制细菌感染期间IFN-γ的产生调节自然杀伤细胞介导的先天免疫。
DOI：
10.3390/ijms21249499
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发表时间：
2020-12-14
影响因子：
5.6
通讯作者：
Jung H
中科院分区：
文献类型：
--
作者：
Kim DO;Byun JE;Kim WS;Kim MJ;Choi JH;Kim H;Choi E;Kim TD;Yoon SR;Noh JY;Park YJ;Lee J;Cho HJ;Lee HG;Min SH;Choi I;Jung H
The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNIP inhibited the production of IFN-γ and the activation of transforming growth factor β-activated kinase 1 (TAK1) activity in primary mouse and human NK cells. TXNIP directly interacted with TAK1 and inhibited TAK1 activity by interfering with the complex formation between TAK1 and TAK1 binding protein 1 (TAB1). Txnip−/− (KO) NK cells enhanced the activation of macrophages by inducing IFN-γ production during Pam3CSK4 stimulation or Staphylococcus aureus (S. aureus) infection and contributed to expedite the bacterial clearance. Our findings suggest that NK cell-derived IFN-γ is critical for host defense and that TXNIP plays an important role as an inhibitor of NK cell-mediated macrophage activation by inhibiting the production of IFN-γ during bacterial infection.
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影响因子：
56.9
作者：
Ge, BX;Gram, H;Han, JH
通讯作者：
Han, JH
影响因子：
5.6
作者：
Hirata Y;Takahashi M;Morishita T;Noguchi T;Matsuzawa A
通讯作者：
Matsuzawa A
影响因子：
29
作者：
Jung, Haiyoung;Kim, Mi Jeong;Choi, Inpyo
通讯作者：
Choi, Inpyo
影响因子：
4.4
作者：
Kim, Min;Osborne, Naomi R.;Cunningham, Anthony L.
通讯作者：
Cunningham, Anthony L.
DOI：
10.1016/0167-4781(94)90242-9
发表时间：
1994-09-13
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
CHEN, KS;DELUCA, HF
通讯作者：
DELUCA, HF