Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors.
Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors.
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DOI：
10.7150/ntno.88892
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Tsourkas A
中科院分区：
文献类型：
--
作者：
Tian Y;Carrillo-Malani N;Feng K;Miller J;Busch TM;Sundaram KM;Cheng Z;Amirshaghaghi A;Tsourkas A
背景：由于近红外吸收、光稳定性、成像对比度和临床试验证明的安全性，酞菁(PC)和萘(NC)染料长期以来一直被用作光学成像和光疗的透光剂。然而，这些染料中只有一小部分被评估为用于癌症治疗的光热疗法(PTT)试剂。方法：通过水包油乳液将近40种不同的NC和PC染料包埋在聚乙二醇PCL胶束中。通过体内和体外研究，确定了用于PTT和光声成像的最佳NC/PC胶束配方。结果：最有前景的CuNC(Octa)胶束显示出较强的PA信号，其峰值吸收峰位于~870 nm，光热效率高，光稳定性好。负载CuNC(Octa)的胶束表现出与金纳米棒/纳米壳一样好或更好的生热效果，并且光声信号提高了10倍。胶束制备具有可重复性/可伸缩性，负载CuNC(Octa)的胶束在生理条件下高度稳定。负载CuNC(Octa)的胶束通过增强的渗透性和滞留作用定位在肿瘤内，并且很容易通过PA成像检测到。在三阴性乳腺癌的同基因小鼠肿瘤模型中，负载CuNC(Octa)的胶束显示PTT有效地产生热量，导致肿瘤完全根除。结论：CuNC(Octa)胶束是一种很有前途的PA显像剂和PTT治疗剂。利用常规超声与PA成像相结合的能力，可以同时获取有关肿瘤形态和胶束积累的信息。载CuNC(Octa)胶束的PTT可彻底根除高侵袭性肿瘤。
Background: Phthalocyanine (PC) and naphthalocyanine (NC) dyes have long garnered interest as theranostic agents for optical imaging and phototherapy due to their near-infrared absorbance, photostability, imaging contrast, and proven safety in clinical trials. Yet, only a small fraction of these dyes has been evaluated as photothermal therapy (PTT) agents for cancer treatment. Methods: Nearly 40 distinct NC and PC dyes were encapsulated within polymeric PEG-PCL micelles via oil-in-water emulsions. The optimal NC/PC-loaded micelle formulations for PTT and photoacoustic (PA) imaging were identified through in vivo and in vitro studies. Results: The most promising candidate, CuNC(Octa)-loaded micelles, demonstrated a strong PA signal with a peak absorbance at ~870 nm, high photothermal efficiency, and photostability. The CuNC(Octa)-loaded micelles exhibited heat generation as good or better than gold nanorods/nanoshells and >10-fold higher photoacoustic signals. Micelle preparation was reproducible/scalable, and the CuNC(Octa)-loaded micelles are highly stable under physiological conditions. The CuNC(Octa)-loaded micelles localize within tumors via enhanced permeability and retention and are readily detectable by PA imaging. In a syngeneic murine tumor model of triple-negative breast cancer, CuNC(Octa)-loaded micelles demonstrate efficient heat generation with PTT, leading to the complete eradication of tumors. Conclusions: CuNC(Octa)-loaded micelles represent a promising theranostic agent for PA imaging and PTT. The ability to utilize conventional ultrasound in combination with PA imaging enables the simultaneous acquisition of information about tumor morphology and micelle accumulation. PTT with CuNC(Octa)-loaded micelles can lead to the complete eradication of highly invasive tumors.
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影响因子：
3.4
作者：
Chen, Zhenyue;Dean-Ben, Xose Luis;Razansky, Daniel
通讯作者：
Razansky, Daniel
影响因子：
6.7
作者：
Jiang, Yuxiang;Tan, Zhuomin;Peng, Zhili
通讯作者：
Peng, Zhili
临床试验装置研究中金纳米壳局部光热消融前列腺肿瘤
DOI：
10.1073/pnas.1906929116
发表时间：
2019-09-10
影响因子：
11.1
作者：
Rastinehad, Ardeshir R.;Anastos, Harry;Halas, Naomi J.
通讯作者：
Halas, Naomi J.
DOI：
10.3390/molecules28010364
发表时间：
2023-01-02
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Li CH;Chan MH;Chang YC;Hsiao M
通讯作者：
Hsiao M
影响因子：
4.7
作者：
Ranyuk, Elena;Lebel, Rejean;Guerin, Brigitte
通讯作者：
Guerin, Brigitte