Temporary Versus Permanent Synaptic Loss from Repeated Noise Exposure in Guinea Pigs and C57 Mice
Temporary Versus Permanent Synaptic Loss from Repeated Noise Exposure in Guinea Pigs and C57 Mice
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豚鼠和 C57 小鼠反复暴露于噪声导致的暂时性与永久性突触丧失
DOI：
10.1016/j.neuroscience.2020.02.038
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发表时间：
2020-02
期刊：
影响因子：
3.3
通讯作者：
Wang Jian
中科院分区：
文献类型：
--
作者：
Zhang Zhen;Fan Liqiang;Xing Yazhi;Wang Jiping;Aiken Steve;Chen Zhengnong;Wang Jian
A single brief noise exposure can cause a significant loss of cochlear afferent synapses without causing permanent threshold shift. Previously we reported that the initial synaptic loss is partially reversible in Guinea pigs, indicating that synaptic loss can be categorized as either temporary or permanent. Since synaptic loss is biased to innervating auditory nerve fibers (ANFs) with low spontaneous spike rates (SSR), which are critical to the coding of in-background noise, coding-in-noise deficits (CIND) have been predicted to result from noise-induced synaptic damage. However, recent study of the noise masking of amplitude-modulation (AM) evoked compound action potentials (CAP) tailed to find evidence for such deficits in either mice or Guinea pigs. The present study sought to determine the effects of repeated noise exposure on temporary and permanent synaptic loss in Guinea pigs and C57 mice, whether such effects were additive, and whether repeated noise exposure induced CIND in Guinea pigs. The results show that the second noise exposure caused much less temporary synaptic loss and no additional permanent loss in Guinea pigs; however, an additional permanent loss was seen after the second noise was in the mice, although it was not significant. In Guinea pigs, the observed increased masking of the AM CAP provides evidence for CIND after repeated noise exposure.
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DOI：
10.1523/jneurosci.5027-12.2013
发表时间：
2013-03-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Maison SF;Usubuchi H;Liberman MC
通讯作者：
Liberman MC
影响因子：
2.8
作者：
W. S. Rhode;P. Smith
通讯作者：
W. S. Rhode;P. Smith
进行隐藏听力损失的诊断测试。
影响因子：
2.7
作者：
Plack CJ;Léger A;Prendergast G;Kluk K;Guest H;Munro KJ
通讯作者：
Munro KJ
影响因子：
7.7
作者：
Wan G;Gómez-Casati ME;Gigliello AR;Liberman MC;Corfas G
通讯作者：
Corfas G
影响因子：
3.7
作者：
Shi L;Liu L;He T;Guo X;Yu Z;Yin S;Wang J
通讯作者：
Wang J