Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage.
Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage.
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DOI：
10.1371/journal.pone.0081566
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Shi L;Liu L;He T;Guo X;Yu Z;Yin S;Wang J
低水平或低剂量的噪声暴露可以损害毛细胞传入带突触，而不会引起永久性的阈值移位。与小鼠耳蜗的报道相反，豚鼠耳蜗带状突触的初始损伤在很大程度上是可修复的。在本研究中，我们进一步研究了类似噪声暴露后豚鼠带状突触的修复过程。在对照样本中，一小部分传入突触缺乏突触带，表明传统的无带突触和带突触共存。毛细胞条带和突触后密度（psd）的丢失和恢复是并行发生的，但恢复不完全，导致不到10%的突触永久性丢失。在修复过程中，色带暂时与psd分离。带状和突触后末端之间的塑性相互作用可能参与了带状和psd之间突触接触的重建，这可以从两个结构的位置变化中看出。突触修复与时间处理的中断有关，这反映在听神经对时间应激信号的复合动作电位（CAP）较差的反应上。因此，颞加工功能的退化源于耳蜗。这种退化随着听力阈值和带状突触计数的恢复而发展，表明修复的突触在时间处理中存在缺陷。
Noise exposure at low levels or low doses can damage hair cell afferent ribbon synapses without causing permanent threshold shifts. In contrast to reports in the mouse cochleae, initial damage to ribbon synapses in the cochleae of guinea pigs is largely repairable. In the present study, we further investigated the repair process in ribbon synapses in guinea pigs after similar noise exposure. In the control samples, a small portion of afferent synapses lacked synaptic ribbons, suggesting the co-existence of conventional no-ribbon and ribbon synapses. The loss and recovery of hair cell ribbons and post-synaptic densities (PSDs) occurred in parallel, but the recovery was not complete, resulting in a permanent loss of less than 10% synapses. During the repair process, ribbons were temporally separated from the PSDs. A plastic interaction between ribbons and postsynaptic terminals may be involved in the reestablishment of synaptic contact between ribbons and PSDs, as shown by location changes in both structures. Synapse repair was associated with a breakdown in temporal processing, as reflected by poorer responses in the compound action potential (CAP) of auditory nerves to time-stress signals. Thus, deterioration in temporal processing originated from the cochlea. This deterioration developed with the recovery in hearing threshold and ribbon synapse counts, suggesting that the repaired synapses had deficits in temporal processing.
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DOI：
10.1682/jrrd.2005.01.0006
发表时间：
2005-07-01
影响因子：
--
作者：
Gordon-Salant, S
通讯作者：
Gordon-Salant, S
DOI：
10.1111/j.1749-6632.1999.tb08640.x
发表时间：
1999-01-01
期刊：
OTOTOXICITY: BASIC SCIENCE AND CLINICAL APPLICATIONS
影响因子：
--
作者：
Ding, DL;Wang, J;Mueller, M
通讯作者：
Mueller, M
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
DOI：
10.1007/s00359-011-0687-9
发表时间：
2012-01-01
影响因子：
2.1
作者：
Gall, Megan D.;Henry, Kenneth S.;Lucas, Jeffrey R.
通讯作者：
Lucas, Jeffrey R.
影响因子：
2.8
作者：
PUJOL, R;LENOIR, M;JOHNSTONE, BM
通讯作者：
JOHNSTONE, BM