Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study.
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study.
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DOI：
10.3389/fcvm.2020.591946
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发表时间：
2020
影响因子：
3.6
通讯作者：
Park C
中科院分区：
文献类型：
--
作者：
Al Saikhan L;Alobaida M;Bhuva A;Chaturvedi N;Heasman J;Hughes AD;Jones S;Eastwood S;Manisty C;March K;Ghosh AK;Mayet J;Oguntade A;Tillin T;Williams S;Wright A;Park C
背景：生活在英国的南亚和非洲加勒比民族的人有很高的心脏代谢疾病的风险。关于该人群中详细的心脏代谢表型的数据有限。方法使这是广泛可用的，但在大规模和不同的样本进行这样的研究的实际方面很少报道。方法：绍瑟尔和布伦特再访（SABRE）研究是英国最大的三种族纵向队列研究。超过1，400名存活参与者（58 - 85岁）参加了第二次研究访视（2008 - 2011）;在此期间，进行了全面的心血管表型分析，包括3D超声心动图[3D斑点追踪（3D-STE）]、计算机断层扫描、冠状动脉钙评分、脉搏波速度、中心血压、颈动脉超声和视网膜成像。我们描述了所使用的方法，目的是提供一个指导，他们的可行性和重现性在一个大型的三种族人口为基础的老年人的研究。结果如下：常规超声心动图和所有血管测量显示出较高的可行性（> 90%的临床参与者可分析），但3D超声心动图（3DE）和3D-STE的可行性较低（71%的3DE采集可行性和38%的3D-STE可行性）。3D-STE可行性因种族而异，南亚参与者最低，非洲加勒比参与者最高（p <0.0001）。在男性（P <0.0001）和女性（P = 0.005）中观察到类似的趋势;然而，在南亚人中，与男性相比，女性有更多的不可读的3D图像（67%对58%）。对于大多数传统和先进的超声心动图测量，观察者内和观察者间的变异性非常好。常规和高级超声心动图测量的重测重复性分别为良好-极好和一般-良好，但低于重读相同图像时的重复性。所有血管测量均显示出极好或一般-良好的重现性。结论：我们描述了在不同种族人群中进行详细心血管表型分型的可行性和可重复性。收集的数据将有助于更好地了解为什么南亚和非洲加勒比血统的人患心脏代谢疾病的风险较高。
Background: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking such studies in large and diverse samples are seldom reported. Methods: The Southall and Brent Revisited (SABRE) study is the UK's largest tri-ethnic longitudinal cohort. Over 1,400 surviving participants (58–85 years) attended the 2nd study visit (2008–2011); during which, comprehensive cardiovascular phenotyping, including 3D-echocardiography [3D-speckle-tracking (3D-STE)], computed tomography, coronary artery calcium scoring, pulse wave velocity, central blood pressure, carotid artery ultrasound, and retinal imaging, were performed. We describe the methods used with the aim of providing a guide to their feasibility and reproducibility in a large tri-ethnic population-based study of older people. Results: Conventional echocardiography and all vascular measurements showed high feasibility (>90% analyzable of clinic attendees), but 3D-echocardiography (3DE) and 3D-STE were less feasible (71% 3DE acquisition feasibility and 38% 3D-STE feasibility of clinic attendees). 3D-STE feasibility differed by ethnicity, being lowest in South Asian participants and highest in African Caribbean participants (p < 0.0001). Similar trends were observed in men (P < 0.0001) and women (P = 0.005); however, in South Asians, there were more women with unreadable 3D-images compared to men (67 vs. 58%). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and advanced echocardiographic measures, respectively, but lower than when re-reading the same images. All vascular measures demonstrated excellent or fair-good reproducibility. Conclusions: We describe the feasibility and reproducibility of detailed cardiovascular phenotyping in an ethnically diverse population. The data collected will lead to a better understanding of why people of South Asian and African Caribbean ancestry are at elevated risk of cardiometabolic diseases.
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影响因子：
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作者：
Du Bois, D;Du Bois, EF
通讯作者：
Du Bois, EF
DOI：
10.1016/j.echo.2013.10.002
发表时间：
2014-01-01
影响因子：
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发表时间：
2012-01-01
影响因子：
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