The Roles of Type I Interferon in Bacterial Infection.

The Roles of Type I Interferon in Bacterial Infection.
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DOI:
10.1016/j.chom.2016.05.016
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发表时间:
2016-06-08
影响因子:
30.3
通讯作者:
Cheng G
Cheng G
中科院分区:
医学1区
文献类型:
--
作者:
Boxx GM;Cheng G

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Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the induction of a potent anti-viral gene program essential for host defense against viruses. They also modulate innate and adaptive immune responses. However, the role of type I IFNs in host defense against bacterial infections is enigmatic. Depending on the bacterium, they exert seemingly opposite and capricious functions. In this review we summarize the effect of type I IFNs on specific bacterial infections and highlight the effector mechanisms regulated by type I IFNs in an attempt to elucidate new avenues to understanding their role.
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