Mucosal-homing natural killer cells are associated with aging in persons living with HIV.
Mucosal-homing natural killer cells are associated with aging in persons living with HIV.
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DOI：
10.1016/j.xcrm.2022.100773
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发表时间：
2022-10-18
影响因子：
14.3
通讯作者：
Reeves, R. Keith
中科院分区：
文献类型：
--
作者：
Kroll, Kyle W.;Shah, Spandan, V;Lucar, Olivier A.;Premeaux, Thomas A.;Shikuma, Cecilia M.;Corley, Michael J.;Mosher, Matthew;Woolley, Griffin;Bowler, Scott;Ndhlovu, Lishomwa C.;Reeves, R. Keith
自然杀伤（NK）细胞是HIV传播和疾病的关键调节剂。最近的证据表明，NK细胞的细胞毒性在衰老过程中的损失，但NK细胞生物学和艾滋病毒（PWH）的人老化的分析是缺乏的。在此，我们对携带和不携带艾滋病毒的老年人进行了全面分析，以确定与年龄相关的NK表型变化。利用高维流式细胞术，我们分析了30个免疫相关蛋白的外周NK细胞从健康的捐助者，PWH与病毒抑制，和病毒血症PWH。NK细胞表型在衰老过程中是动态的，但在HIV和抗逆转录病毒药物治疗（ART）中变化显著。健康老年人NK细胞表达增加，CCR7表达减少，而PWH则相反。这些HIV相关的运输模式可能是由于NK细胞募集到淋巴组织中的HIV储库形成或HIV感染肠道中的粘膜信号传导失败，但似乎是年龄相关NK细胞变化的严格描述。衰老过程中的NK细胞显示来自衰老PWH的肠道归巢标记物CCR4 β7 NK细胞的表达增加，无论治疗如何，上调淋巴结归巢CCR7 CMV状态似乎不会显著影响PWH中的NK细胞运输ART的进展导致艾滋病毒感染者（PWH）人口老龄化。NK细胞在病毒控制中起着关键作用，并且在衰老中也表现出不同的贩运标记模式。衰老PWH中粘膜和淋巴结归巢的破坏可能对淋巴结中的病毒控制和肠道内稳态具有显著影响。
Natural killer (NK) cells are critical modulators of HIV transmission and disease. Recent evidence suggests a loss of NK cell cytotoxicity during aging, yet analysis of NK cell biology and aging in people with HIV (PWH) is lacking. Herein, we perform comprehensive analyses of people aging with and without HIV to determine age-related NK phenotypic changes. Utilizing high-dimensional flow cytometry, we analyze 30 immune-related proteins on peripheral NK cells from healthy donors, PWH with viral suppression, and viremic PWH. NK cell phenotypes are dynamic across aging but change significantly in HIV and on antiretroviral drug therapy (ART). NK cells in healthy aging show increasing ⍺4β7 and decreasing CCR7 expression and a reverse phenomenon in PWH. These HIV-associated trafficking patterns could be due to NK cell recruitment to HIV reservoir formation in lymphoid tissue or failed mucosal signaling in the HIV-infected gut but appear to be tight delineators of age-related NK cell changes. NK cells during aging display increasing expression of gut-homing marker ⍺4β7 NK cells from aging PWH, regardless of treatment, upregulate lymph node-homing CCR7 CMV status does not appear to significantly impact NK cell trafficking in PWH Advances in ART have led to an aging population of people living with HIV (PWH). NK cells play a key role in viral control and also demonstrate distinct trafficking-marker patterns in aging. Disruption of mucosal and lymph node homing in aging PWH could have significant impacts on virus control in lymph nodes and gut homeostasis.
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DOI：
10.1155/2018/7871814
发表时间：
2018
期刊：
Analytical cellular pathology (Amsterdam)
影响因子：
--
作者：
Gounder SS;Abdullah BJJ;Radzuanb NEIBM;Zain FDBM;Sait NBM;Chua C;Subramani B
通讯作者：
Subramani B
影响因子：
7.3
作者：
Huot N;Bosinger SE;Paiardini M;Reeves RK;Müller-Trutwin M
通讯作者：
Müller-Trutwin M
DOI：
10.1016/s0140-6736(08)61113-7
发表时间：
2008-07-26
期刊：
Lancet (London, England)
影响因子：
--
作者：
Antiretroviral Therapy Cohort Collaboration
通讯作者：
Antiretroviral Therapy Cohort Collaboration
影响因子：
82.9
作者：
Huot N;Jacquelin B;Garcia-Tellez T;Rascle P;Ploquin MJ;Madec Y;Reeves RK;Derreudre-Bosquet N;Müller-Trutwin M
通讯作者：
Müller-Trutwin M
DOI：
10.1073/pnas.2022928118
发表时间：
2021-04-06
影响因子：
11.1
作者：
Lopez Angel CJ;Pham EA;Du H;Vallania F;Fram BJ;Perez K;Nguyen T;Rosenberg-Hasson Y;Ahmed A;Dekker CL;Grant PM;Khatri P;Maecker HT;Glenn JS;Davis MM;Furman D
通讯作者：
Furman D