Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition.
Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition.
复制标题
DOI：
10.1155/2018/7871814
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Subramani B
中科院分区：
文献类型：
--
作者：
Gounder SS;Abdullah BJJ;Radzuanb NEIBM;Zain FDBM;Sait NBM;Chua C;Subramani B
自然杀伤(NK)细胞种群、表型和功能的年龄相关变化直接归因于几种疾病和感染的风险。据预测，这将是死亡率上升的主要原因。根据CD56的表面密度，NK细胞分为CD56bright细胞和CD56dim细胞两种类型，它们代表细胞因子的产生和细胞毒作用。在我们的研究中，我们研究了不同年龄组的男性和女性(从41岁到80岁)自然杀伤细胞及其亚群的年龄相关变化。我们发现，随着年龄的增长，男女的淋巴细胞总数都显著下降。然而，随着年龄的增长，总免疫细胞水平也有所下降，令人惊讶的是，总NK细胞数量显著增加，其中大部分是CD56dim。随后，我们对NK细胞的增殖能力进行了评估，结果表明，NK细胞的增殖能力随着年龄的增长而下降。总体而言，我们的发现证明，随着年龄的增长，循环中的NK细胞数量会增加。然而，与年轻年龄组(<；41 )相比，随着年龄的增长，增殖率下降。
Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two types, such as CD56bright and CD56dim cells, which represent cytokine production and cytotoxicity. In our study, we have examined the age-associated changes in the NK cell population and their subsets at different age groups of males and females (at a range from 41 to 80 years). We found that the total lymphocyte count significantly dropped upon aging in both genders. Although, the level of total immune cells also dropped on aging, and surprisingly the total NK cell population was remarkably increased with the majority of NK cells being CD56dim. Subsequently, we evaluated the proliferation potential of NK cells and our results showed that the NK cell proliferation ability declines with age. Overall, our findings prove that there is an increase in the circulating NK cell population upon aging. However, the proliferation rate upon aging declines when compared to the young age group (<41 yrs).
登录
查看更多内容
影响因子：
7.3
作者：
Fasbender F;Widera A;Hengstler JG;Watzl C
通讯作者：
Watzl C
影响因子：
8
作者：
Sagiv, A.;Biran, A.;Yon, M.;Simon, J.;Lowe, S. W.;Krizhanovsky, V.
通讯作者：
Krizhanovsky, V.
DOI：
10.1111/j.1749-6632.1992.tb38685.x
发表时间：
1992-11-21
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
KIRKWOOD, TBL;FRANCESCHI, C
通讯作者：
FRANCESCHI, C
影响因子：
6.4
作者：
Schmidt, Stanislaw;Tramsen, Lars;Lehrnbecher, Thomas
通讯作者：
Lehrnbecher, Thomas
影响因子：
13.1
作者：
Hazeldine, Jon;Lord, Janet M.
通讯作者：
Lord, Janet M.