Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells.
Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells.
复制标题
DOI：
10.3390/md9040603
复制
发表时间：
2011
期刊：
影响因子：
5.4
通讯作者：
Oliveira Rocha HA
中科院分区：
文献类型：
--
作者：
Silva Costa L;Silva Telles CB;Medeiros Oliveira R;Duarte Barreto Nobre LT;Dantas-Santos N;Barros Gomes Camara R;Santana Santos Pereira Costa M;Almeida-Lima J;Melo-Silveira RF;Lopes Albuquerque IR;Leite EL;Oliveira Rocha HA
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer.
登录
查看更多内容
影响因子：
6.2
作者：
Scarinci, Isabel C.;Garcia, Francisco A. R.;Kobetz, Erin;Partridge, Edward E.;Brandt, Heather M.;Bell, Maria C.;Dignan, Mark;Ma, Grace X.;Daye, Jane L.;Castle, Philip E.
通讯作者：
Castle, Philip E.
通过Lipoic Acid调节细胞周期过渡和HL-60白血病细胞中凋亡的诱导：预防癌症和治疗中的作用。
影响因子：
28.5
作者：
Selvakumar E;Hsieh TC
通讯作者：
Hsieh TC
DOI：
10.3390/molecules13081671
发表时间：
2008-08-12
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Li B;Lu F;Wei X;Zhao R
通讯作者：
Zhao R
影响因子：
5.1
作者：
Choi, Jong-il;Raghavendran, Hanumatha Rao Balaji;Lee, Ju-Woon
通讯作者：
Lee, Ju-Woon
影响因子：
12.8
作者：
Aisa, Y;Miyakawa, Y;Kizaki, M
通讯作者：
Kizaki, M