Early Sensory Deprivation Leads to Differential Inhibitory Changes in the Striatum During Learning.
Early Sensory Deprivation Leads to Differential Inhibitory Changes in the Striatum During Learning.
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DOI：
10.3389/fncir.2021.670858
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发表时间：
2021
影响因子：
3.5
通讯作者：
Mowery TM
中科院分区：
文献类型：
--
作者：
Paraouty N;Mowery TM
皮质纹状体回路已被确定为联想学习的重要途径。然而，当感觉纹状体永久性受损时如何进行学习仍不清楚。使用化学遗传学技术抑制第五层听觉皮层（AC）对听觉纹状体的输入，自由移动的蒙古沙鼠的声音辨别任务的学习受到显着影响，特别是当这种抑制发生在学习过程的早期时。在学习过程中采样的全细胞记录显示，正常听力沙鼠在任务习得过程中，纹状体 D1 和 D2 细胞的突触后 (GABAA) 抑制短暂减少。相反，当基线纹状体抑制强度和放电率因短暂的发育性感觉剥夺而永久降低时，学习伴随着抑制增强和放电率增加。体内和体外纹状体抑制的直接操作揭示了短暂抑制变化在任务获取中的关键作用。总之，这些结果揭示了伴随联想听觉学习的灵活的皮质纹状体抑制性突触可塑性机制。
The corticostriatal circuit has been identified as a vital pathway for associative learning. However, how learning is implemented when the sensory striatum is permanently impaired remains unclear. Using chemogenetic techniques to suppress layer five auditory cortex (AC) input to the auditory striatum, learning of a sound discrimination task was significantly impacted in freely moving Mongolian gerbils, in particular when this suppression occurs early on during learning. Whole-cell recordings sampled throughout learning revealed a transient reduction in postsynaptic (GABAA) inhibition in both striatal D1 and D2 cells in normal-hearing gerbils during task acquisition. In contrast, when the baseline striatal inhibitory strengths and firing rates were permanently reduced by a transient period of developmental sensory deprivation, learning was accompanied by augmented inhibition and increased firing rates. Direct manipulation of striatal inhibition in vivo and in vitro revealed a key role of the transient inhibitory changes in task acquisition. Together, these results reveal a flexible corticostriatal inhibitory synaptic plasticity mechanism that accompanies associative auditory learning.
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影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
3.7
作者：
Goodliffe JW;Song H;Rubakovic A;Chang W;Medalla M;Weaver CM;Luebke JI
通讯作者：
Luebke JI
影响因子：
2.5
作者：
Bosman, LWJ;Heinen, K;Brussaard, AB
通讯作者：
Brussaard, AB
影响因子：
2.5
作者：
Baarbe, Julianne;Yielder, Paul;Murphy, Bernadette
通讯作者：
Murphy, Bernadette
影响因子：
25
作者：
Cho, K;Kemp, N;Bashir, ZI
通讯作者：
Bashir, ZI