Hippo signalling in the liver: role in development, regeneration and disease.
Hippo signalling in the liver: role in development, regeneration and disease.
复制标题
Hippo在肝脏中的信号传导：在发育、再生和疾病中的作用。
DOI：
10.1038/s41575-021-00571-w
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
Hippo信号通路已经成为肝脏生物学许多方面的主要参与者，如肝脏发育，细胞命运决定，稳态功能和损伤再生。Hippo信号传导的调节是复杂的，该通路的激活来自不同的上游输入，包括来自细胞粘附、机械转导和与其他信号传导通路的串扰的信号。Hippo信号负调控下游转录辅激活因子yes相关蛋白1（雅普）和转录辅激活因子PDZ结合基序（TAZ）的病理激活，参与慢性肝病的多个方面，如肝纤维化和肿瘤的发生。因此，雅普/TAZ信号传导的药理学抑制剂的开发一直是非常感兴趣的领域。在这篇综述中，我们总结了Hippo信号在肝脏生物学中的不同作用，并强调了仍有待研究的突出问题。更好地了解Hippo信号在肝功能中的作用机制将有助于促进肝病治疗新疗法的开发。
The Hippo signaling pathway has emerged as a major player in many aspects of liver biology, such as liver development, cell fate determination, homeostatic function, and regeneration from injury. The regulation of Hippo signaling is complex, with activation of the pathway coming from diverse upstream inputs including signals from cellular adhesion, mechanotransduction, and crosstalk with other signaling pathways. Pathological activation of the downstream transcriptional co-activators yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are negatively regulated by Hippo signaling, has been implicated in multiple aspects of chronic liver disease, such as the development of liver fibrosis and tumorigenesis. As such, development of pharmacological inhibitors of YAP/TAZ signaling has been an area of great interest. In this review, we summarize the diverse roles of Hippo signaling in liver biology and highlight areas where outstanding questions remain to be investigated. Greater understanding of the mechanisms of Hippo signaling in liver function should help to facilitate the development of novel therapies for the treatment of liver disease.
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影响因子：
64.8
作者：
Chang L;Azzolin L;Di Biagio D;Zanconato F;Battilana G;Lucon Xiccato R;Aragona M;Giulitti S;Panciera T;Gandin A;Sigismondo G;Krijgsveld J;Fassan M;Brusatin G;Cordenonsi M;Piccolo S
通讯作者：
Piccolo S
影响因子：
16.8
作者：
Bangru S;Arif W;Seimetz J;Bhate A;Chen J;Rashan EH;Carstens RP;Anakk S;Kalsotra A
通讯作者：
Kalsotra A
影响因子：
8.8
作者：
Alder O;Cullum R;Lee S;Kan AC;Wei W;Yi Y;Garside VC;Bilenky M;Griffith M;Morrissy AS;Robertson GA;Thiessen N;Zhao Y;Chen Q;Pan D;Jones SJM;Marra MA;Hoodless PA
通讯作者：
Hoodless PA
对 NF2/Merlin 肿瘤抑制功能的分子见解。
影响因子：
3.5
作者：
Cooper J;Giancotti FG
通讯作者：
Giancotti FG
影响因子：
4.8
作者：
Creasy, CL;Ambrose, DM;Chernoff, J
通讯作者：
Chernoff, J