Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy.
Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy.
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DOI：
10.1016/j.freeradbiomed.2014.03.035
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发表时间：
2014-07
影响因子：
7.4
通讯作者：
Jiang, Qing
中科院分区：
文献类型：
--
作者：
Jiang, Qing
关键词：
维生素E家族由四种生育酚和四种生育三烯酚组成。α-生育酚（αT）是组织中维生素E的主要形式，其缺乏会导致人类共济失调。然而，许多临床研究的结果并不支持αT在营养状况充足的人群中预防疾病的保护作用。另一方面，最近的机制研究表明，其他形式的维生素E，如γ-生育酚（γT），δ-生育酚（δT）和γ-生育三烯酚（γTE）具有独特的抗氧化和抗炎特性，在预防和治疗慢性疾病方面上级αT。这些维生素E形成活性氮物质，抑制环氧合酶和5-脂氧合酶催化的类花生酸，并抑制促炎信号传导，如NF-κB和STAT 3/6。与αT不同，其他维生素E形式通过细胞色素P-450（CYP 4F 2）启动的侧链ω-氧化显著代谢为羧基色原烷醇。长链羧基苯并二氢吡喃醇，特别是13 '-羧基苯并二氢吡喃醇，显示出比未代谢的维生素具有更强的抗炎作用，因此可能有助于维生素E形式在体内的有益作用。与机制发现一致，动物和人类研究表明γT和生育三烯酚可能对炎症相关疾病有用。本文综述了维生素E的非αT形式的代谢、抗炎作用和机制以及在临床前模型和人体临床干预研究中的体内功效。
The Vitamin E family consists of four tocopherols and four tocotrienols. α-Tocopherol (αT) is the predominant form of vitamin E in tissues and its deficiency leads to ataxia in humans. However, results from many clinical studies do not support protective roles of αT in disease prevention in people with adequate nutrient status. On the other hand, recent mechanistic studies indicate that other forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT) and γ-tocotrienol (γTE) have unique antioxidant and anti-inflammatory properties that are superior to αT in prevention and therapy against chronic diseases. These vitamin E forms scavenge reactive nitrogen species, inhibit cyclooxygenase- and 5-lipoxygenase-catalyzed eicosanoids and suppress pro-inflammatory signaling such as NF-κB and STAT3/6. Unlike αT, other vitamin E forms are significantly metabolized to carboxychromanols via cytochrome P-450 (CYP4F2)-initiated side-chain ω-oxidation. Long-chain carboxychromanols, esp.13’-carboxychromanols, are shown to have stronger anti-inflammatory effects than un-metabolized vitamins and may therefore contribute to beneficial effects of vitamin E forms in vivo. Consistent with mechanistic findings, animal and human studies show that γT and tocotrienols may be useful against inflammation-associated diseases. This review focuses on non-αT forms of vitamin E with respect to their metabolism, anti-inflammatory effects and mechanisms and in vivo efficacy in preclinical models as well as human clinical intervention studies.
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影响因子：
4.3
作者：
Chun, J;Lee, J;Eitenmiller, RR
通讯作者：
Eitenmiller, RR
DOI：
10.1196/annals.1331.012
发表时间：
2004-01-01
期刊：
VITAMIN E AND HEALTH
影响因子：
--
作者：
Gohil, K;Godzdanker, R;Traber, MG
通讯作者：
Traber, MG
DOI：
10.1073/pnas.90.5.1771
发表时间：
1993-03-01
影响因子：
11.1
作者：
COONEY, RV;FRANKE, AA;MORDAN, LJ
通讯作者：
MORDAN, LJ
影响因子：
5.9
作者：
Fanning, Laura B.;Boyce, Joshua A.
通讯作者：
Boyce, Joshua A.
影响因子：
7.4
作者：
Devaraj, Sridevi;Leonard, Scott;Jialal, Ishwarlal
通讯作者：
Jialal, Ishwarlal