TURN-IT: a novel turning intervention program to improve quality of turning in daily life in people with Parkinson's disease.
TURN-IT: a novel turning intervention program to improve quality of turning in daily life in people with Parkinson's disease.
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DOI：
10.1186/s12883-022-02934-5
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发表时间：
2022-11-28
期刊：
影响因子：
2.6
通讯作者：
Horak, F. B.
中科院分区：
文献类型：
--
作者：
King, L. A.;Carlson-Kuhta, P.;Wilhelm, J. L.;Lapidus, J. A.;Dale, M. L.;Talman, L. S.;Barlow, N.;Mancini, M.;Horak, F. B.
帕金森病（PD）患者的跌倒率很高，许多福尔斯都与转弯有关。尽管如此，关于康复对转弯质量的影响的研究很少。此外，量化家中的转弯可能具有更广泛的含义，因为转弯的恢复将理想地改善真实的世界移动性中的转弯。将60名有福尔斯跌倒史的PD患者随机分为两组，一组接受新型TURNing干预（TURN-IT），另一组不接受干预（对照组）。TURN-IT组将接受为期6周（18次访视）的个性化渐进计划，该计划基于PD的特定限制。可穿戴传感器将用于测量干预或控制期前后7天的移动性，包括转弯。此外，将在干预前后对两组进行步态、活动性和转身的盲态评估，并在干预后12个月内通过每两个月一次的电子邮件问卷监测福尔斯。这项研究有可能改变我们康复和评估PD和福尔斯患者的方式。我们的研究有几个新的方面，包括一个全面的转向为重点的干预，是专门针对潜在的限制，损害转向的人与PD。此外，我们在7天的日常生活中转向质量的结果测量是新颖的，并对确定康复后的现实生活变化具有影响。这种康复干预的最终目标是改善患者在日常生活中的转身方式并减少福尔斯跌倒。该方案在clinicaltrials.gov;#NCT 04897256; https://clinicaltrials.gov/ct2/show/NCT04897256?上注册term=Horak&cond=Parkinson+Disease&draw=2&rank=4.在线版本包含补充材料，可通过10.1186/s12883-022-02934-5获得。
People with Parkinson’s disease (PD) have a high fall rate and many falls are associated with turns. Despite this, there is minimal research on effects of rehabilitation on the quality of turns. Further, quantifying turns in the home may have broader implications since rehabilitation of turns would ideally improve turning in real world mobility. Sixty people with PD and a history of falls will be randomized to receive either a novel TURNing InTervention (TURN-IT) or no intervention (control group). The TURN-IT group will be seen for 6 weeks (18 visits) for an individualized, progressive program that is based on the specific constraints of turning in PD. Wearable sensors will be used to measure 7 days of mobility, including turns, before and after intervention or control period. In addition, blinded assessments of gait, mobility and turns will occur before and after intervention for both groups and falls will be monitored for twelve months post intervention with bimonthly email questionnaires. This study has the potential to change how we rehabilitate and assess turning in people with PD and falls. There are several novel aspects to our study including a comprehensive turning-focused intervention that is tailored to the underlying constraints that impair turning in people with PD. Further, our outcome measure of turning quality during 7 days of daily life is novel and has implications for determining real-life changes after rehabilitation. The ultimate goal of this rehabilitation intervention is to improve how patients turn in daily life and to reduce falls. This protocol is registered at clinicaltrials.gov; #NCT04897256; https://clinicaltrials.gov/ct2/show/NCT04897256?term=Horak&cond=Parkinson+Disease&draw=2&rank=4. The online version contains supplementary material available at 10.1186/s12883-022-02934-5.
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DOI：
10.1155/2013/572134
发表时间：
2013
期刊：
Parkinson's disease
影响因子：
--
作者：
King LA;Salarian A;Mancini M;Priest KC;Nutt J;Serdar A;Wilhelm J;Schlimgen J;Smith M;Horak FB
通讯作者：
Horak FB
影响因子：
6.3
作者：
Florence CS;Bergen G;Atherly A;Burns E;Stevens J;Drake C
通讯作者：
Drake C
影响因子：
1.7
作者：
Grasso, R;Glasauer, S;Berthoz, A
通讯作者：
Berthoz, A
影响因子：
3.5
作者：
Franchignoni F;Horak F;Godi M;Nardone A;Giordano A
通讯作者：
Giordano A
影响因子：
2.4
作者：
Anson, Eric;Thompson, Elizabeth;Jeka, John
通讯作者：
Jeka, John