Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis.
Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis.
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DOI：
10.3390/antibiotics10060698
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发表时间：
2021-06-10
期刊：
影响因子：
--
通讯作者：
López-López J
中科院分区：
文献类型：
--
作者：
Roca-Millan E;Estrugo-Devesa A;Merlos A;Jané-Salas E;Vinuesa T;López-López J
在植入过程中，常规使用全身抗生素，但缺乏共识导致临床医生对抗生素预防方案存在很大差异。本系统综述的目的是评估处方抗生素以预防早期种植失败的必要性，并找到最合适的抗生素预防方案。在PubMed/MEDLINE、Scielo和Cochrane中央试验数据库中进行电子检索，检索至少随访3个月的随机临床试验。11项研究纳入定性分析。抗生素可显著降低早期种植失败（RR = 0.30, 95% CI: 0.19-0.47, p < 0.00001；异质性I2 = 0%, p = 0.54）。术前和术后抗生素治疗方案之间无差异（RR = 0.57, 95% CI: 0.21-1.55, p = 0.27；异质性I2 = 0%, p = 0.37）。与不使用抗生素相比，术前单一抗生素预防剂量足以显著减少早期种植失败（RR = 0.34, 95% CI: 0.21-0.53, p < 0.00001；异质性I2 = 0%, p = 0.61）。总之，在健康患者中，单剂量抗生素预防可预防早期种植失败。
Systemic antibiotics are routinely prescribed in implant procedures, but the lack of consensus causes large differences between clinicians regarding antibiotic prophylaxis regimens. The objectives of this systematic review are to assess the need to prescribe antibiotics to prevent early implant failure and find the most appropriate antibiotic prophylaxis regimen. The electronic search was conducted in PubMed/MEDLINE, Scielo and Cochrane Central Trials Database for randomized clinical trials of at least 3 months of follow-up. Eleven studies were included in the qualitative analysis. Antibiotics were found to statistically significantly reduce early implant failures (RR = 0.30, 95% CI: 0.19–0.47, p < 0.00001; heterogeneity I2 = 0%, p = 0.54). No differences were seen between preoperative or both pre- and postoperative antibiotic regimens (RR = 0.57, 95% CI: 0.21–1.55, p = 0.27; heterogeneity I2 = 0%, p = 0.37). A single preoperative antibiotic prophylaxis dose was found to be enough to significantly reduce early implant failures compared to no antibiotic (RR = 0.34, 95% CI: 0.21–0.53, p < 0.00001; heterogeneity I2 = 0%, p = 0.61). In conclusion, in healthy patients a single antibiotic prophylaxis dose is indicated to prevent early implant failure.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
2.9
作者：
Korsch M;Marten SM;Stoll D;Prechtl C;Dötsch A
通讯作者：
Dötsch A
影响因子：
3.6
作者：
Kashani, Hossein;Hilon, Jack;Friberg, Bertil
通讯作者：
Friberg, Bertil
影响因子：
6
作者：
Pokrowiecki R
通讯作者：
Pokrowiecki R
影响因子：
11.8
作者：
Lofmark, Sonja;Edlund, Charlotta;Nord, Carl Erik
通讯作者：
Nord, Carl Erik