Microbiological findings in early and late implant loss: an observational clinical case-controlled study.
Microbiological findings in early and late implant loss: an observational clinical case-controlled study.
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DOI：
10.1186/s12903-021-01439-w
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发表时间：
2021-03-11
期刊：
影响因子：
2.9
通讯作者：
Dötsch A
中科院分区：
文献类型：
--
作者：
Korsch M;Marten SM;Stoll D;Prechtl C;Dötsch A
种植体是一种可预测的和公认的牙科治疗方法。然而，在牙科植入物的可能失败，早期和晚期损失必须加以区分。本研究旨在报告种植体表面的微生物发现，严重的种植体周围炎，必须进行预防。对48例无严重全身疾病患者的53个种植体标本进行了检查。研究的组是在骨整合期（早期丢失，13例患者14个种植体）或愈合期后（晚期丢失，14例患者17个种植体）必须取出的种植体。将种植体丢失与两个对照组（种植体植入后2 - 4个月完成骨整合后直接无骨丢失的种植体（17例患者，17个种植体）和种植体无骨丢失和修复超过3年的种植体（5例患者，5个种植体））进行比较。使用16 S rRNA基因的扩增和高通量测序收集关于位于种植体周围沟中的细菌的数据。生物膜组成个体之间差异很大。在早期和晚期种植体丢失中，发现有核梭杆菌和牙龈卟啉单胞菌都很丰富。晚期丢失的植入物显示出更高的细菌多样性，此外，密螺旋体，Fretibacterium，假不动杆菌和脱硫杆菌的丰度更高，而早期丢失的植入物的微生物群落是非常异质的，并没有显示出显着更丰富的细菌类群。在种植体周围发现了特定的种植体周围病原体，这些病原体在基本上顺利的骨整合后丢失。牙龈卟啉单胞菌和F.在早期和晚期丢失中，核质经常定殖于植入物，因此通常可以是植入物丢失的特征。一般来说，早期丢失的植入物也显示出比晚期丢失更低的微生物多样性。然而，微生物结果并不能说明早期和晚期损失的原因。
Implants are a predictable and well-established treatment method in dentistry. Nevertheless, looking at possible failures of dental implants, early and late loss have to be distinguished. The intent of the study was to report microbiological findings on the surface of implants with severe peri-implantitis, which had to be explanted. 53 specimens of implants from 48 patients without severe general illnesses have been examined. The groups investigated were implants that had to be removed in the period of osseointegration (early loss, 13 patients with 14 implants) or after the healing period (late loss, 14 patients with 17 implants). The implant losses were compared with two control groups (implants with no bone loss directly after completed osseointegration, two to four months after implant placement (17 patients with 17 implants) and implants with no bone loss and prosthetic restoration for more than three years (5 patients with 5 implants)). Data about the bacteria located in the peri-implant sulcus was collected using amplification and high throughput sequencing of the 16S rRNA gene. The biofilm composition differed substantially between individuals. Both in early and late implant loss, Fusobacterium nucleatum and Porphyromonas gingivalis were found to be abundant. Late lost implants showed higher bacterial diversity and in addition higher abundances of Treponema, Fretibacterium, Pseudoramibacter and Desulfobulbus, while microbial communities of early loss implants were very heterogeneous and showed no significantly more abundant bacterial taxa. Specific peri-implant pathogens were found around implants that were lost after a primarily uneventful osseointegration. P. gingivalis and F. nucleatum frequently colonized the implant in early and late losses and could therefore be characteristic for implant loss in general. In general, early lost implants showed also lower microbial diversity than late losses. However, the microbial results were not indicative of the causes of early and late losses.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
2.3
作者：
Chrcanovic, Bruno Ramos;Kisch, Jeno;Wennerberg, Ann
通讯作者：
Wennerberg, Ann
影响因子：
--
作者：
Friedman, Paula K;Kaufman, Laura B;Karpas, Steven L
通讯作者：
Karpas, Steven L
DOI：
10.1007/978-3-319-11038-7_5
发表时间：
2015-01-01
期刊：
BIOFILM-BASED HEALTHCARE-ASSOCIATED INFECTIONS, VOL I
影响因子：
--
作者：
Faveri, Marcelo;Figueiredo, Luciene Cristina;Feres, Magda
通讯作者：
Feres, Magda
影响因子：
2
作者：
Gupta, Bhumija;Acharya, Aneesha;Kolokythas, Antonia
通讯作者：
Kolokythas, Antonia