Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity.
Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity.
复制标题
肠上皮内淋巴细胞：肠道免疫耐受的维持者和肠道免疫的调节者
DOI：
10.1002/jlb.3ru0220-111
复制
发表时间：
2021-03
影响因子：
5.5
通讯作者：
Yang H
中科院分区：
文献类型：
--
作者：
Ma H;Qiu Y;Yang H
肠道免疫耐受对于免疫系统至关重要，因为它可以防止对肠腔大量抗原（例如共生微生物抗原）的异常免疫反应，并避免自我伤害。肠上皮内淋巴细胞（IELs）是一种特殊的粘膜T淋巴细胞，在肠道免疫耐受中起重要作用。为了实现这一点，IEL表现出高活化阈值和对来自肠腔的大多数抗原的低反应性。特别是CD8αα+TCRαβ+ IEL、TCRγδ+ IEL和CD4+CD8αα+ IEL在维持肠道免疫耐受和调节肠道免疫方面显示出巨大潜力。然而，如果肠道微环境变得异常或肠道耐受性被破坏，IEL可能会被异常激活并成为致病性的。综述了肠上皮内淋巴细胞如何维持肠道免疫耐受，调节肠道免疫，参与乳糜泻。
Intestinal immune tolerance is essential for the immune system, as it prevents abnormal immune responses to large quantities of antigens from the intestinal lumen, such as antigens from commensal microorganisms, and avoids self‐injury. Intestinal intraepithelial lymphocytes (IELs), a special group of mucosal T lymphocytes, play a significant role in intestinal immune tolerance. To accomplish this, IELs exhibit a high threshold of activation and low reactivity to most antigens from the intestinal lumen. In particular, CD8αα+TCRαβ+ IELs, TCRγδ+ IELs, and CD4+CD8αα+ IELs show great potential for maintaining intestinal immune tolerance and regulating intestinal immunity. However, if the intestinal microenvironment becomes abnormal or intestinal tolerance is broken, IELs may be activated abnormally and become pathogenic. Review focuses on how intestinal intraepithelial lymphocytes maintain intestinal immune tolerance, regulate intestinal immunity, and participate in celiac disease.
鼠类上皮内淋巴细胞的免疫调节功能：γ/Delta T细胞受体阳性（TCR+）T细胞消除口服耐受性，而α/βTCR+ TCR+ TCR细胞可提供B细胞帮助。
影响因子：
15.3
作者：
FUJIHASHI, K;TAGUCHI, T;AICHER, WK;MCGHEE, JR;BLUESTONE, JA;ELDRIDGE, JH;KIYONO, H
通讯作者：
KIYONO, H