Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
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百里醌可防止斯普拉格-道利大鼠阿霉素诱导的心力衰竭造成的心脏损伤
DOI：
10.1039/c8ra00975a
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发表时间：
2018-04-17
期刊：
影响因子：
3.9
通讯作者：
Yu, Qin
中科院分区：
文献类型：
--
作者：
Pei, Zuowei;Hu, Jiahui;Bai, Qianru;Liu, Baiting;Cheng, Dong;Liu, Hainiang;Na, Rongmei;Yu, Qin
心力衰竭是多种心血管疾病的复杂终末期结果，预后不良。心力衰竭的发生和发展机制一直是心血管研究的重要课题，既往的研究表明，百里醌（TQ）可以保护心脏毒性和心脏损伤。本研究的目的是探讨百里醌对阿霉素（DOX）诱导的SD大鼠（SDR）心力衰竭心脏损伤的可能保护作用。将45例男性SDR随机分为3组，分别给予不同的治疗方案，疗程8周。DOX + TQ组左室短轴缩短率（LVFS）和射血分数（LVEF）均高于DOX组。与DOX + TQ组相比，DOX组大鼠观察到显著的病理生理学变化（HE和Masson染色）。加入百里醌可抑制SDR中DOX诱导的心脏纤维化（TGF-β、Smad 3、胶原I、胶原III和α-SMA）和细胞凋亡（P53、bcl-2、caspase-3、caspase-9和BAX），表明百里醌可能是DOX诱导的心力衰竭引起的心脏损伤的潜在治疗靶点。
Heart failure is a complex end stage result of various cardiovascular diseases, and has a poor prognosis. The mechanisms for the development and progression of heart failure have always been an important topic in cardiovascular research, and previous studies have shown that thymoquinone (TQ) protects against cardiotoxicity and cardiac damage. The aim of this study was to investigate the possible protective effects of thymoquinone against cardiac damage in doxorubicin (DOX)-induced heart failure in Sprague-Dawley Rats (SDR). Forty-five male SDR were randomly divided into three groups and administered different treatment regimens for 8 weeks. Left ventricular fractional shortening (LVFS) and ejection fraction (LVEF) were higher in the DOX + TQ group than those in the DOX group. Significant pathophysiology changes (HE and Masson staining) were observed in rats of the DOX group compared to those of the DOX + TQ group. The addition of Thymoquinone inhibited DOX-induced cardiac fibrosis (TGF-β, Smad3, collagen I, collagen III, and α-SMA) and apoptosis (P53, bcl-2, caspase-3, caspase-9, and BAX) in SDR, indicating that thymoquinone may be a potential therapeutic target for cardiac damage caused by DOX-induced heart failure.
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影响因子：
8.3
作者：
Petrov, VV;Fagard, RH;Lijnen, PJ
通讯作者：
Lijnen, PJ
百里醌通过激活的肝星状细胞中的 PI3K 和 TLR4 信号通路减轻肝纤维化
影响因子：
5.6
作者：
Bai, Ting;Lian, Li-Hua;Nan, Ji-Xing
通讯作者：
Nan, Ji-Xing
影响因子：
10.8
作者：
Lee, Paul J. H.;Rudenko, Dmitriy;Leong-Poi, Howard
通讯作者：
Leong-Poi, Howard
影响因子：
37.8
作者：
Condorelli, G;Morisco, C;Lembo, G
通讯作者：
Lembo, G
DOI：
10.1016/j.bbrc.2011.12.063
发表时间：
2012-01-13
影响因子：
3.1
作者：
Lei, Xiaofei;Lv, Xiaoguang;Dong, Weiguo
通讯作者：
Dong, Weiguo