Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat.
Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat.
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饮食蛋白的来源有助于达尔盐敏感大鼠患孕产妇综合征的风险。
DOI：
10.1016/j.preghy.2021.04.002
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Mattson DL
中科院分区：
文献类型：
--
作者：
Dasinger JH;Abais-Battad JM;Bukowy JD;Lund H;Alsheikh AJ;Fehrenbach DJ;Zemaj J;Mattson DL
先兆子痫（PE）是一种妊娠期疾病，其分类为高血压和蛋白尿或终末器官损伤的体征。尽管PE是孕产妇和胎儿发病和死亡的主要原因，但导致PE的机制仍不清楚。本研究利用两个 Dahl 盐敏感 (SS/JrHsdMcwi) 大鼠群体，研究了膳食蛋白质来源（酪蛋白与小麦麸质）对发生母体综合症的风险的影响。虽然菌落之间的唯一区别是饮食，但菌落在妊娠表型上表现出巨大的差异。坚持食用小麦麸质（SSWG）食物的 SS 大鼠可以免受母体综合症的影响；然而，大约一半喂以酪蛋白为主的饮食（SSC）的 SS 大鼠表现出母体综合症。与受保护的 SS 大鼠相比，那些出现妊娠特异性血压和蛋白尿升高的 SSC 大鼠的肾脏或胎盘免疫特征没有明显差异。胎盘组织的基因谱阵列显示，SSC 大鼠中 Nos3 和 Cyp26a1 下调，这些大鼠出现母体综合征并伴有子宫动脉阻力指数增加，表明这种表型的来源可能与胎盘内重塑不足有关。对多胎妊娠对孕产妇健康影响的调查也得到了类似的结果。 SSC 群体表现出蛋白尿、肾肥大和肾脏免疫细胞浸润的恶化，并与死亡率增加相关，而 SSWG 群体则受到保护，凸显了膳食蛋白质来源如何对 PE 产生有益影响。
Preeclampsia (PE) is a disorder of pregnancy, which is categorized by hypertension and proteinuria or signs of end-organ damage. Though PE is the leading cause of maternal and fetal morbidity and mortality, the mechanisms leading to PE remain unclear. The present study examined the contribution of dietary protein source (casein versus wheat gluten) to the risk of developing maternal syndrome utilizing two colonies of Dahl salt-sensitive (SS/JrHsdMcwi) rats. While the only difference between the colonies is the diet, the colonies exhibit profound differences in the pregnancy phenotypes. The SS rats maintained on the wheat gluten (SSWG) chow are protected from developing maternal syndrome; however, approximately half of the SS rats fed a casein-based diet (SSC) exhibit maternal syndrome. Those SSC rats that develop pregnancy-specific increases in blood pressure and proteinuria have no observable differences in renal or placental immune profiles compared to the protected SS rats. A gene profile array of placental tissue revealed a downregulation in Nos3 and Cyp26a1 in the SSC rats that develop maternal syndrome accompanied with increases in uterine artery resistance index suggesting the source of this phenotype could be linked to inadequate remodeling within the placenta. Investigations into the effects of multiple pregnancies on maternal health replicated similar findings. The SSC colony displayed an exacerbation in proteinuria, renal hypertrophy and renal immune cell infiltration associated with an increased mortality rate while the SSWG colony were protected highlighting how dietary protein source could have beneficial effects in PE.
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影响因子：
7.1
作者：
Arvizu, Mariel;Stuart, Jennifer J.;Chavarro, Jorge E.
通讯作者：
Chavarro, Jorge E.
影响因子：
2.7
作者：
Fehrenbach DJ;Dasinger JH;Lund H;Zemaj J;Mattson DL
通讯作者：
Mattson DL
DOI：
10.1161/hypertensionaha.114.04179
发表时间：
2015-02
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Geurts AM;Mattson DL;Liu P;Cabacungan E;Skelton MM;Kurth TM;Yang C;Endres BT;Klotz J;Liang M;Cowley AW Jr
通讯作者：
Cowley AW Jr
影响因子：
6.3
作者：
Abais-Battad, Justine M.;Saravia, Fatima L.;Lund, Hayley;Dasinger, John Henry;Fehrenbach, Daniel J.;Alsheikh, Ammar J.;Zemaj, Jeylan;Kirby, John R.;Mattson, David L.
通讯作者：
Mattson, David L.
在子宫耐药性高的早期人类妊娠中，血管重塑的决定性自然杀伤细胞调节受损。
影响因子：
7.3
作者：
Fraser, Rupsha;Whitley, Guy Stj;Johnstone, Alan P.;Host, Amanda J.;Sebire, Neil J.;Thilaganathan, Baskaran;Cartwright, Judith E.
通讯作者：
Cartwright, Judith E.