8-Iso-Prostaglandin F2α, a Product of Noise Exposure, Reduces Inner Ear Blood Flow
8-Iso-Prostaglandin F2α, a Product of Noise Exposure, Reduces Inner Ear Blood Flow
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8-异前列腺素 F2α（噪音暴露的产物）会减少内耳血流量
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Schacht
中科院分区：
文献类型：
--
作者：
Josef M. Miller;J. N. Brown;J. Schacht
噪声暴露诱导耳蜗中8-异前列腺素F2α（8-iso-PGF 2 α）的形成，8-iso-PGF 2 α是活性氧的标志物[Ohinata et al.，2000 a]和一种有效的血管收缩剂，增加了8-iso-PGF 2 α可能是噪声诱导的耳蜗血流量（CBF）减少的原因的可能性。为了验证这一假设，在豚鼠中评估CBF对“局部”（通过小脑前下动脉）和全身（i. v.）使用激光多普勒血流仪递送8-iso-PGF 2 α。局部8-iso-PGF 2 α诱导CBF明显降低。全身输注后，血管传导性（VC）（CBF与全身血压的比值）以剂量依赖性方式降低高达30%，与8-iso-PGF 2 α诱导的耳蜗血管收缩一致。8-iso-PGF 2 α的特异性拮抗剂SQ 29548可适当阻断8-iso-PGF 2 α诱导的CBF反应。同样，噪声引起的CBF和VC的变化被防止SQ 29548在噪声暴露期间或通过抗氧化剂处理（谷胱甘肽单乙酯）之前曝光的输注。预防异前列腺素介导的血管收缩可能在预防噪声性听力损失方面具有临床实用性。
Noise exposure induces the formation in the cochlea of 8-isoprostaglandin F2α (8-iso-PGF2α), a marker for reactive oxygen species [Ohinata et al., 2000a] and a potent vasoconstrictor, raising the possibility that 8-iso-PGF2α may be responsible for noise-induced reductions in cochlear blood flow (CBF). To test this hypothesis, CBF was assessed in the guinea pig in response to ‘local’ (via the anterior inferior cerebellar artery) and systemic (i.v.) delivery of 8-iso-PGF2α using laser Doppler flowmetry. Local 8-iso-PGF2α induced a clear reduction in CBF. With systemic infusion, vascular conductance (VC), the ratio of CBF to systemic blood pressure, decreased in a dose-dependent manner up to 30%, consistent with an 8-iso-PGF2α-induced constriction of the cochlear vasculature. Infusion of SQ29548, a specific antagonist of 8-iso-PGF2α, appropriately blocked an 8-iso-PGF2α-induced CBF response. Similarly, noise-induced changes in CBF and VC were prevented by infusion of SQ29548 during noise exposure or by antioxidant treatment (glutathione monoethyl ester) prior to exposure. Prevention of isoprostane-mediated vasoconstriction may have clinical utility in the protection from noise-induced hearing loss.
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DOI：
10.1152/ajprenal.1997.272.4.f477
发表时间：
1997
期刊：
The American journal of physiology
影响因子：
--
作者：
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影响因子：
5.8
作者：
Morrow, JD;Roberts, LJ
通讯作者：
Roberts, LJ
影响因子：
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作者：
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通讯作者：
NEWMAN, JH
DOI：
10.1073/pnas.87.23.9383
发表时间：
1990-12-01
影响因子：
11.1
作者：
MORROW, JD;HILL, KE;ROBERTS, LJ
通讯作者：
ROBERTS, LJ