Remarkable Stability of Myelinating Oligodendrocytes in Mice.
Remarkable Stability of Myelinating Oligodendrocytes in Mice.
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DOI：
10.1016/j.celrep.2017.09.050
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发表时间：
2017-10-10
期刊：
影响因子：
8.8
通讯作者：
Richardson WD
中科院分区：
文献类型：
--
作者：
Tripathi RB;Jackiewicz M;McKenzie IA;Kougioumtzidou E;Grist M;Richardson WD
新的髓鞘形成少突胶质细胞（OL）在成年小鼠中枢神经系统中产生。这些成年出生的OL可能会增加现有的人口，促进神经可塑性，或者取代在使用中死亡的OL（更替）。为了区分这些替代品，我们在年轻的成年小鼠中诱导成熟髓鞘形成OL的遗传标记，并跟踪其随后的存活率。OL生存率具有区域依赖性，胼胝体（20个月内生存率为0.90%）和运动皮质（生存率为0.70%）高于皮质脊髓束或视神经（生存率为50%-60%）。除视神经外，所有区域的前8个月存活率为90%-100%。在胼胝体中，新的OL在青年期积累，因此可能参与适应性髓鞘形成。我们还发现，由单个皮质OL维持的髓磷脂节间的数量至少在8个月内是稳定的，但在第二年下降了约12%。髓鞘形成少突胶质细胞（OL）在成年小鼠CNS中继续发育，它们可能取代垂死的OL或有助于新的（适应性）髓鞘形成。我们通过Opalin-iCreERT 2：Tau-mGFP小鼠的遗传命运作图估计OL寿命。通过Opalin-CreERT 2：Tau-mGFP小鼠中的命运作图估计髓鞘形成少突胶质细胞（OL）的寿命。在胼胝体中，>90%的OL存活>1.5年，并且可能比小鼠寿命长。因此，成人出生的OL不需要髓鞘稳态，但可能有助于经验依赖性，适应性髓鞘形成。
New myelin-forming oligodendrocytes (OLs) are generated in the mouse central nervous system during adulthood. These adult-born OLs might augment the existing population, contributing to neural plasticity, or else replace OLs that die in use (turnover). To distinguish between these alternatives, we induced genetic labeling of mature myelinating OLs in young adult mice and tracked their subsequent survival. OL survival rates were region dependent, being higher in corpus callosum (∼90% survival over 20 months) and motor cortex (∼70% survival) than in corticospinal tract or optic nerve (50%–60% survival). Survival rates over the first 8 months were 90%–100% in all regions except the optic nerve. In the corpus callosum, new OLs accumulate during young adulthood and are therefore likely to participate in adaptive myelination. We also found that the number of myelin internodes maintained by individual cortical OLs is stable for at least 8 months but declines ∼12% in the following year. Myelinating oligodendrocytes (OLs) continue to develop in the adult mouse CNS They might replace dying OLs or else contribute to new (adaptive) myelination We estimated OL lifetime by genetic fate-mapping in Opalin–iCreERT2: Tau–mGFP mice In most regions, >90% of OLs survive >8 months, so most new OLs are probably adaptive Tripathi et al. estimate the lifetime of myelinating oligodendrocytes (OLs) by fate-mapping in Opalin-CreERT2: Tau-mGFP mice. In the corpus callosum, >90% of OLs survived for >1.5 years and probably outlive the mouse. Therefore, adult-born OLs are not needed for myelin homeostasis but potentially contribute to experience-dependent, adaptive myelination.
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影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
DOI：
10.1007/bf00305064
发表时间：
1989-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
GORGELS, TGMF;DEKORT, EJM;NIEUWENHUYS, R
通讯作者：
NIEUWENHUYS, R
影响因子：
2.5
作者：
SKOFF, RP;PRICE, DL;STOCKS, A
通讯作者：
STOCKS, A
影响因子：
1.7
作者：
Uematsu, J;Ono, K;Shimada, M
通讯作者：
Shimada, M
神经元活动会影响体内髓鞘形成的轴突选择。
影响因子：
25
作者：
Hines, Jacob H.;Ravanelli, Andrew M.;Schwindt, Rani;Scott, Ethan K.;Appel, Bruce
通讯作者：
Appel, Bruce