Expression of ribosome-binding protein 1 correlates with shorter survival in Her-2 positive breast cancer.
Expression of ribosome-binding protein 1 correlates with shorter survival in Her-2 positive breast cancer.
复制标题
核糖体结合蛋白 1 的表达与 Her-2 阳性乳腺癌的较短生存期相关。
DOI：
10.1111/cas.12666
复制
发表时间：
2015-06
期刊：
影响因子：
5.7
通讯作者：
Pang D
中科院分区：
文献类型：
--
作者：
Liang X;Sun S;Zhang X;Wu H;Tao W;Liu T;Wei W;Geng J;Pang D
本研究旨在探讨核糖体结合蛋白1（RRBP 1）在浸润性乳腺癌中的表达及其与临床特征和预后的关系。RRBP 1的表达进行了研究，使用实时定量PCR和蛋白质印迹配对匹配的乳腺样品和免疫组化染色，使用组织芯片。分析RRBP 1表达与临床病理特征的关系。乳腺癌组织中RRBP 1 mRNA和蛋白表达均显著高于正常组织。RRBP 1蛋白表达水平与组织学分级（P = 0.02）、分子亚型（P = 0.048）、Her-2（P = 0.026）和P53（P = 0.015）呈正相关。我们根据RRBP 1表达水平对所有患者进行了等级分层分析，发现RRBP 1过表达高度影响早期（I和II）肿瘤患者的总生存率（P = 0.042）。RRBP 1阴性表达的Her-2阳性患者的总生存率高于RRBP 1阳性表达的患者（P = 0.031）。多因素分析显示，淋巴结转移（LNM，P = 0.002）和RRBP 1表达（P = 0.005）是影响总生存率的独立预后因素。RRBP 1在Her-2阳性乳腺癌患者中是一个有价值的预后因子，表明RRBP 1是预测预后的潜在重要靶点。
The aim of this study is to investigate the expression of ribosome-binding protein 1 (RRBP1) in invasive breast cancer and to analyze its relationship to clinical features and prognosis. RRBP1 expression was studied using real-time quantitative PCR and western blotting using pair-matched breast samples and immunohistochemical staining using a tissue microarray. Then the correlation between RRBP1 expression and clinicopathologic features was analyzed. RRBP1 mRNA and protein expression were significantly increased in breast cancer tissues compared with normal tissues. The protein level of RRBP1 is proved to be positively related to histological grade (P = 0.02), molecular subtype (P = 0.048) and status of Her-2 (P = 0.026) and P53 (P = 0.015). We performed a grade-stratified analysis of all patients according to the level of RRBP1 expression and found that RRBP1 overexpression highly affected overall survival in patients with early-stage (I and II) tumors (P = 0.042). Furthermore, Her-2 positive patients with negative RRBP1 expression had longer overall survival rates than those with positive RRBP1 expression (P = 0.031). Using multivariate analysis, it was determined that lymph node metastasis (LNM, P = 0.002) and RRBP1 expression (P = 0.005) were independent prognosis factors for overall survival. RRBP1 is a valuable prognostic factor in Her-2-positive breast cancer patients, indicating that RRBP1 is a potentially important target for the prediction of prognosis.
登录
查看更多内容
影响因子：
4.1
作者：
Gomez, Edith;Powell, Mike L.;Herbert, Terence P.
通讯作者：
Herbert, Terence P.
影响因子：
64.8
作者：
Cho, HS;Mason, K;Leahy, DJ
通讯作者：
Leahy, DJ
影响因子：
21.3
作者：
Feng, B;Yao, PM;Tabas, I
通讯作者：
Tabas, I
影响因子：
11.2
作者：
Clarke R;Cook KL;Hu R;Facey CO;Tavassoly I;Schwartz JL;Baumann WT;Tyson JJ;Xuan J;Wang Y;Wärri A;Shajahan AN
通讯作者：
Shajahan AN
DOI：
10.1083/jcb.200112008
发表时间：
2002-03-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hyde M;Block-Alper L;Felix J;Webster P;Meyer DI
通讯作者：
Meyer DI