Systematic review of diarrhea duration and severity in children and adults in low- and middle-income countries.
Systematic review of diarrhea duration and severity in children and adults in low- and middle-income countries.
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DOI：
10.1186/1471-2458-12-276
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发表时间：
2012-04-06
影响因子：
4.5
通讯作者：
Black RE
中科院分区：
文献类型：
--
作者：
Lamberti LM;Fischer Walker CL;Black RE
腹泻是全球发病率和死亡率的主要原因;但腹泻在持续时间和严重程度方面的总体负担尚未量化。由于治疗的改善导致腹泻死亡率下降，因此了解腹泻发病率对全球儿童和成人残疾的实质性影响非常重要。我们进行了一项系统性综述，以估计0-59个月、5-15岁和≥ 16岁个体的持续时间和严重程度结局，以及3个严重程度指数：轻度、中度和重度。我们估计，在五岁以下儿童中，64.8%的腹泻发作是轻度的，34.7%是中度的，0.5%是重度的。平均而言，轻度发作持续4.3天，重度发作持续8.4天，84.6%的病例会导致脱水。我们估计，在年龄较大的儿童和成人中，95%的发作是轻度的; 4.95%是中度的; 0.05%是重度的。在≥ 16岁的个体中，重度发作通常持续2.6天，92.8%的病例会导致脱水。中度和重度腹泻占五岁以下儿童腹泻总发病率的很大一部分（35.2%;约5.88亿次）。在年龄较大的儿童和成人中，中度和重度发作占腹泻总包络的比例要小得多（5%），但此类发作的绝对数量值得注意（在≥ 16岁的个体中约有2150万次发作）。因此，腹泻的全球负担包括显著的发病率，超过进展至死亡的发作。
Diarrhea is a leading cause of morbidity and mortality globally; yet the overall burden of diarrhea in terms of duration and severity has not been quantified. As improvements in treatment lead to decreases in diarrhea mortality, it is important to understand the substantial impact of diarrhea morbidity on disability among children and adults worldwide. We conducted a systematic review to generate estimates of duration and severity outcomes for individuals 0-59 mos, 5-15 yrs, and ≥ 16 yrs, and for 3 severity indexes: mild, moderate, and severe. We estimate that among children under-five, 64.8% of diarrheal episodes are mild, 34.7% are moderate, and 0.5% are severe. On average, mild episodes last 4.3 days, and severe episodes last 8.4 days and cause dehydration in 84.6% of cases. We estimate that among older children and adults, 95% of episodes are mild; 4.95% are moderate; and 0.05% are severe. Among individuals ≥ 16 yrs, severe episodes typically last 2.6 days and cause dehydration in 92.8% of cases. Moderate and severe episodes constitute a substantial portion of the total envelope of diarrhea among children under-five (35.2%; about 588 million episodes). Among older children and adults, moderate and severe episodes account for a much smaller proportion of the total envelope of diarrhea (5%), but the absolute number of such episodes is noteworthy (about 21.5 million episodes among individuals ≥ 16 yrs). Hence, the global burden of diarrhea consists of significant morbidity, extending beyond episodes progressing to death.
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影响因子：
6.4
作者：
CLARK, HF;BORIA, FE;PLOTKIN, SA
通讯作者：
PLOTKIN, SA
DOI：
10.1590/s1413-86702003000600006
发表时间：
2003-12-01
期刊：
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
影响因子：
--
作者：
Castro, Melania X;Soares, Alberto M;Lima, Aldo A M
通讯作者：
Lima, Aldo A M
影响因子：
1.5
作者：
Chan, SSW;Ng, KC;Rainer, TH
通讯作者：
Rainer, TH
DOI：
10.1016/s0035-9203(96)90315-6
发表时间：
1996-09-01
影响因子：
2.2
作者：
Gupta, DN;Sircar, BK;Saha, NC
通讯作者：
Saha, NC
影响因子：
5
作者：
FERRECCIO, C;PRADO, V;LEVINE, MM
通讯作者：
LEVINE, MM