Association between Obesity and Puberty Timing: A Systematic Review and Meta-Analysis.
Association between Obesity and Puberty Timing: A Systematic Review and Meta-Analysis.
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肥胖与青春期时间之间的关联：系统回顾和荟萃分析
DOI：
10.3390/ijerph14101266
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发表时间：
2017-10-24
影响因子：
--
通讯作者：
Story M
中科院分区：
文献类型：
--
作者：
Li W;Liu Q;Deng X;Chen Y;Liu S;Story M
这项系统回顾和荟萃分析基于科学证据研究了肥胖和青春期时间之间的关系。截至2017年2月，在8个电子数据库中检索符合条件的研究，由两名审稿人独立筛选文章并提取数据。共有11项队列研究4841名受试者符合纳入标准。与正常体重组相比，肥胖组出现月经初潮的女生较多（RR: 1.87, 95% CI: 1.59-2.19, 2项研究）。肥胖组女生性早熟人数明显高于正常体重组（RR: 2.44, 95% CI: 1.32-4.52, 5项研究）。然而，在初潮年龄肥胖或体重正常的女孩之间没有发现差异（WMD: - 0.53年，95% CI: - 1.24-0.19, 2项研究）。在肥胖和男孩青春期开始的时间之间没有一致的结果。肥胖可能导致女孩过早进入青春期，而对于男孩，尚无足够的数据。考虑到本荟萃分析中纳入的队列研究数量有限，需要高质量的研究，其中包括青春期发病的强烈标记，以及定义肥胖的标准化标准。
This systematic review and meta-analysis examined the associations between obesity and puberty timing based on scientific evidence. Eight electronic databases were searched up to February 2017 for eligible studies, and two reviewers screened the articles and extracted the data independently. A total of 11 cohort studies with 4841 subjects met the inclusion criteria. Compared with the group of normal-weight girls, the obese group had more girls with menarche (RR: 1.87, 95% CI: 1.59–2.19, 2 studies). The number of girls with early puberty was significantly higher in the obese group than the normal weight group (RR: 2.44, 95% CI: 1.32–4.52, 5 studies). However, no differences were detected between girls who were obese or normal weight at age of menarche (WMD: −0.53 years, 95% CI: −1.24–0.19, 2 studies). There is no consistent result in the relationship between obesity and timing of pubertal onset in boys. Obesity may contribute to early onset of puberty in girls, while in boys, there is insufficient data. Given the limited number of cohort studies included in this meta-analysis, high-quality studies with strong markers of puberty onset, as well as standardized criteria for defining obesity are needed.
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影响因子：
4
作者：
Lo CK;Mertz D;Loeb M
通讯作者：
Loeb M
DOI：
10.1073/pnas.0505429103
发表时间：
2006-05-30
影响因子：
11.1
作者：
Chan, Jean L.;Matarese, Giuseppe;Mantzoros, Christos S.
通讯作者：
Mantzoros, Christos S.
影响因子：
5.8
作者：
Bau, A. M.;Ernert, A.;Krude, H.
通讯作者：
Krude, H.
影响因子：
2.5
作者：
Ersoy, B;Balkan, C;Egemen, A
通讯作者：
Egemen, A
影响因子：
15.9
作者：
Ahima, RS;Dushay, J;Flier, JS
通讯作者：
Flier, JS