Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats.
Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats.
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DOI：
10.1002/pros.21017
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发表时间：
2009-11-01
期刊：
影响因子：
2.8
通讯作者：
Lamartiniere, Coral A.
中科院分区：
文献类型：
--
作者：
Harper, Curt E.;Cook, Leah M.;Patel, Brijesh B.;Wang, Jun;Eltoum, Isam A.;Arabshahi, Ali;Shirai, Tomoyuki;Lamartiniere, Coral A.
利用饮食制剂进行化学预防是减缓前列腺癌发展的有效手段。我们评估了染料木黄酮和白藜芦醇在猴病毒-40 T-抗原（SV-40 Tag）靶向probasin启动子大鼠模型（一种自发性前列腺癌的转基因模型）中抑制前列腺癌的潜在累加和协同效应。大鼠单独和联合喂食染料木黄酮或白藜芦醇（250 mg/kg AIN-76 A饮食），以及低剂量组合（83 mg染料木黄酮+83 mg白藜芦醇/kg饮食）。分别在30周龄和12周龄时进行组织学和作用机制研究。染料木黄酮、白藜芦醇和高剂量联合治疗抑制前列腺癌。低剂量复方制剂未引起针对前列腺癌的保护作用，并且很可能低于引起显著组织病理学变化的有效剂量。总染料木黄酮和白藜芦醇浓度在血液中达到2160和211纳米，分别在大鼠暴露于单一治疗。多酚处理降低前列腺细胞增殖和胰岛素样生长因子-1（IGF-1）蛋白表达。此外，染料木黄酮作为一个单一的代理诱导细胞凋亡和减少类固醇受体辅激活因子-3（SRC-3）在腹侧前列腺（VP）。染料木黄酮和白藜芦醇，单独和组合，抑制前列腺癌的发展，在SV-40标签模型。SRC-3和生长因子信号传导蛋白的调节与这些营养多酚在前列腺中减少细胞增殖和增加细胞凋亡一致。
Chemoprevention utilizing dietary agents is an effective means to slow the development of prostate cancer. We evaluated the potential additive and synergistic effects of genistein and resveratrol for suppressing prostate cancer in the Simian Virus-40 T-antigen (SV-40 Tag) targeted probasin promoter rat model, a transgenic model of spontaneously developing prostate cancer. Rats were fed genistein or resveratrol (250 mg/kg AIN-76A diet) alone and in combination, and a low dose combination (83 mg genistein + 83 mg resveratrol/kg diet). Histopathology and mechanisms of action studies were conducted at 30 and 12 weeks of age, respectively. Genistein, resveratrol, and the high dose combination treatments suppressed prostate cancer. The low dose combination did not elicit protection against prostate cancer and was most likely below the effective dose for causing significant histopathological changes. Total genistein and resveratrol concentrations in the blood reached 2160 and 211 nM, respectively in rats exposed to the single treatments. Polyphenol treatments decreased cell proliferation and insulin-like growth factor-1 (IGF-1) protein expression in the prostate. In addition, genistein as a single agent induced apoptosis and decreased steroid receptor coactivator-3 (SRC-3) in the ventral prostate (VP). Genistein and resveratrol, alone and in combination, suppress prostate cancer development in the SV-40 Tag model. Regulation of SRC-3 and growth factor signaling proteins are consistent with these nutritional polyphenols reducing cell proliferation and increasing apoptosis in the prostate.
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影响因子：
1.8
作者：
De Santi, C;Pietrabissa, A;Pacifici, GM
通讯作者：
Pacifici, GM
影响因子：
5.7
作者：
Cho, YM;Takahashi, S;Shirai, T
通讯作者：
Shirai, T
影响因子：
82.9
作者：
Craft, N;Shostak, Y;Sawyers, CL
通讯作者：
Sawyers, CL
DOI：
10.1196/annals.1386.027
发表时间：
2006-01-01
期刊：
ESTROGENS AND HUMAN DISEASES
影响因子：
--
作者：
Carruba, Giuseppe
通讯作者：
Carruba, Giuseppe
影响因子：
2.8
作者：
Harper, Curt E.;Patel, Brijesh B.;Lamartiniere, Coral A.
通讯作者：
Lamartiniere, Coral A.