Glycocalyx volume: a critical review of tracer dilution methods for its measurement.
Glycocalyx volume: a critical review of tracer dilution methods for its measurement.
复制标题
糖脂量：对示踪剂稀释方法进行测量的批判性综述。
DOI：
10.1080/10739680802527404
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Curry FR
中科院分区：
文献类型：
--
作者：
Michel CC;Curry FR
内皮糖萼结构的临床测量将具有巨大的潜在重要性，因为糖萼的病变可能是糖尿病和广泛的血管疾病中发生的第一个变化。Nieuwdorp等人最近描述的用于估计整个人体血管系统的管腔糖萼体积的方法似乎是开发这种测量的第一次尝试。它是基于示踪剂稀释的原则，本次审查认为，这种方法的原则和条件，并在何种程度上的条件似乎已经满足在这种情况下。我们的分析提出了两个问题：（a）在零时示踪剂（葡聚糖40）浓度的估计和（B）血浆体积的估计，这两个问题都可以通过改变实验方案来回答。第三个问题，关于血浆和糖萼内液体之间示踪剂的分配系数，目前无法回答，直到它已经解决，糖萼体积不能估计从大分子示踪剂的稀释。
A clinical measure of endothelial glycocalyx structure would have great potential importance because lesions of the glycocalyx may be the first changes to occur in diabetes and in a wide range of vascular diseases. A method recently described by Nieuwdorp et al for estimating the volume of the luminal glycocalyx of the entire human vascular system would seem to be the first attempt to develop a measure of this kind. It is based on the tracer dilution principle and this review considers the principles and conditions that underlie this method and the extent to which the conditions appear to have been fulfilled in this case. Our analysis raises two questions about (a) the estimation of the concentration of the tracer (dextran 40) at zero time and (b) the estimation of plasma volume, both of which can be answered by changes in experimental protocol. A third question, concerning the partition coefficient of the tracer between plasma and the fluid within the glycocalyx, cannot be answered at the present time and until it has been resolved, glycocalyx volume cannot be estimated from the dilution of a macromolecular tracer.
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影响因子：
3.3
作者：
Reddy, Sai T.;Berk, David A.;Swartz, Melody A.
通讯作者：
Swartz, Melody A.
影响因子：
--
作者：
GARLICK, DG;RENKIN, EM
通讯作者：
RENKIN, EM
影响因子：
3.3
作者：
Nieuwdorp, Max;Meuwese, Marijn C.;Vink, Hans
通讯作者：
Vink, Hans
DOI：
10.1152/ajpheart.2000.278.1.h285
发表时间：
2000-01-01
影响因子：
4.8
作者：
Vink, H;Duling, BR
通讯作者：
Duling, BR
影响因子：
7.7
作者：
Nieuwdorp, M;Mooij, HL;Vink, H
通讯作者：
Vink, H